[Efficacy of adipin and normodipin (generic drugs of amlodipine) vs norvsc in treatment of essential hypertension].

It's well known, that norvsc - a very effective and popular cardiovascular medication - has many generic analogs. The reason of our study was to compare the efficacy and safety of adipin ("GMP", Georgia), normodipin ("Gedeon Richter", Hungary) and norvasc ("Pfizer", USA) in patients with essential hypertension (stage I-II, JNC VII). The study was performed using ambulatory blood pressure monitoring (ABPM), the data from which closely correlate with end-organ damage in hypertension and provides excellent information about hypotensive drug effect on the circadian rhythm of blood pressure and its adequate control.

[C-reactive protein level and rate of detection of autoantibodies to beta(1)-adrenoreceptors in patients with supraventricular tachyarrhythmias].

In order to assess concentration of C-reactive protein (CRP) and prevalence of autoantibodies against beta(1)-adrenoreceptors (abeta(1)-AR) in patients with cardiac supraventricular arrhythmias we studied 53 patients with arrhythmias and 20 healthy control subjects. Patients with idiopathic arrhythmias (atrial fibrillation or flutter and atrial tachycardia, n=35) comprised group I. Group II was formed of 15 patients with supraventricular arrhythmias and dilated cardiomyopathy (DCM) or chronic myocarditis.

[Cardiac sympathetic innervation in patients with ventricular arrhythmias: an assessment by 123I-metaiodobenzylguanidine scintigraphy].

The aim of this study was to determine the state of sympathetic innervation in patients with ventricular arrhythmias (VA) using 123I-metaiodobenzylguanidine 123I -MIBG) scintigraphy. Fifty six patients (26 men and 30 women, mean age 37.4+/-11,6) underwent single-photon emission computed tomography (SPECT) imaging and planner scintigraphy after injection of 123I-MIBG (activity 148 MBq).

[Spectral parameters of heart rate variability and frequency of detection of autoantibodies to beta(1)-adrenoreceptors in patients with tachyarrhythmias: idiopathic and at the background of primary myocardial diseases].

In order to assess parameters of heart rate variability (HRV) and prevalence of autoantibodies against the beta(1)-adrenoreceptors in patients with cardiac arrhythmias we studied 42 patients with arrhythmias and 20 healthy control subjects. Thirty one patients with idiopathic arrhythmias were included in group I: with paroxysmal atrial fibrillation or flutter (n=13), paroxysmal atrial tachycardia (n=2) and paroxysmal ventricular tachycardia (n=16). Group II was formed of 11 patients with paroxysmal ventricular tachycardia and dilated cardiomyopathy or chronic myocarditis.

[Autoantibodies Against beta(1)-Adrenoreceptors in Patients With Cardiac Rhythm Disorders. Prevalence and Possible Role in Development of Arrhythmia].

Aim: To assess prevalence of autoantibodies against beta(1)-adrenoreceptors (beta(1)-AR) in patients with arrhythmias of various etiology.

Material: Patients with arrhythmias (n=110, including 59 patients with primary [idiopathic] electrical abnormalities, 33 - with chronic myocarditis and dilated cardiomyopathy [DCM]; 18 - with ischemic heart disease [IHD]) and healthy control subjects (n=20).

Methods: Antibodies against beta(1)-AR were measured in blood serum by direct immunoassay.