Publications by authors named "N V Litviakov"
It is known that complete pathomorphological response (pCR) after neoadjuvant therapy (NAC) in patients with breast cancer (BC) correlates with higher rates of recurrence-free and overall survival. In turn, the widespread use of neoadjuvant therapy for the treatment of breast cancer defines the clinical need for prognostic markers of response to ongoing therapy. Currently, some clinicopathological prognostic factors are used to assess the potential benefit of neoadjuvant systemic therapy for female patients, but they have limited applicability.
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- Peritoneal carcinomatosis (PC) is a serious condition often found in gastric cancer patients, occurring in 15-52% of cases.
- The study involved 70 patients, with one group receiving standard chemotherapy and another receiving personalized chemotherapy based on genetic analysis of tumors.
- Results showed the personalized treatment group had significantly longer progression-free survival (14.9 months vs. 11.2 months) and overall life expectancy (16.8 months vs. 12.5 months) compared to the standard treatment group.
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- - A new strategy for preventing cancer metastasis involves using a combination of three specific microRNAs (miR-195-5p, miR-520a, and miR-630) that help stop cancer cells from reverting to a stem cell-like state, which is linked to their ability to spread.
- - Researchers conducted transcriptome microarray analysis to observe how these microRNAs affected gene expression in human breast cancer cell lines, finding that the microRNA mixture reduced the cells' ability to form mammosphere clusters in lab conditions.
- - When the microRNAs were delivered in lipid nanoparticles, they effectively prevented lung metastasis in a mouse model, suggesting this combination could lead to promising new treatments that thwart the growth of secondary tumors.
To date, numerous mechanisms have been identified in which one cell engulfs another, resulting in the creation of 'cell-in-cell' (CIC) structures, which subsequently cause cell death. One of the mechanisms of formation of these structures is entosis, which is presumably associated with possible carcinogenesis and tumour progression. The peculiarity of the process is that entotic cells themselves actively invade the host cell, and afterwards have several possible variants of fate.
View Article and Find Full Text PDFTranscriptomic evidence from human myocardium in myocardial infarction (MI) is still not sufficient. Thus, there is a need for studies on human cardiac samples in relation to the clinical data of patients. The purpose of our pilot study was to investigate the transcriptomic profile of myocardium in the infarct zone, in comparison to the remote myocardium, in patients with fatal MI, via microarray analysis.
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