Publications by authors named "N V Kovyazina"
Article Synopsis
- Lung cancer is a major global health issue, influenced by cancer stem cells (CSCs), but the interaction between these CSCs and SARS-CoV2 is not well understood.
- This study compares lung adenocarcinoma samples from 12 patients who had COVID-19 with 12 who did not, examining tumor characteristics and CSC markers.
- Results indicated that patients who had COVID-19 had significantly more CSCs (marked by ALDH1, CD133, and CD34) in their tumors, suggesting that COVID-19 may enhance the metastatic potential of lung adenocarcinoma and the presence of viral proteins in the lung tissue.
Article Synopsis
- Alveolar proteinosis is a rare lung disease where protein-lipid complexes build up in the lungs, disrupting normal function.
- It affects about 2 to 4 people per million adults.
- The text discusses a specific case of this disease in a patient who previously had coronavirus pneumonia.
The complex of climatic and geographical conditions of the Arctic determines the high intensity of the polysystem adaptive response of the organism, the duration of which is additionally influenced by individual genetic characteristics, social conditions, psychological and work loads. Taking into account the relevance of timely prevention and early diagnosis of stress-induced somatic pathology in EMERCOM employees working in unfavorable climatic and geographical zones, the authors evaluated the informative value of determining the level of steroid hormones and insulin as laboratory markers of adaptation to Arctic conditions. The expediency of developing objective criteria for the interpretation of the insulin/cortisol index and studying the informativeness of the 17ONprogesterone level as the earliest marker of adaptation to unfavorable climatic and geographical conditions of the Arctic is substantiated.
View Article and Find Full Text PDFThe detection of stress-induced premature aging with the aim of correcting damaging adaptive effects seems to be actual today. The article discusses the use of the DHEAS / cortisol index as a screening marker for accelerating the rate of biological aging in people exposed to stress.
View Article and Find Full Text PDFNowadays, improving accuracy and clinical informativeness of results of studies is one of main directions of development of laboratory. The article presents originally developed algorithm of evaluation of quality of immunochemical studies in part related to analytical stage. The case of application in practice of the results of such evaluation is presented.
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