Bradykinin-induced shifts in microhemodynamics, lymph production and flow in cat intestine; the effect of gut denervation.

In experiments on anaesthetized cats increased doses of bradykinin were administered intraarterially into an innervated part of the small intestine perfused in situ with constant inflow. It is concluded that the main factor accelerating transcapillary fluid efflux and lymph flow in this region with bradykinin is the rise in permeability of gut capillaries. This is confirmed by elevation in capillary filtration coefficient which takes place on the background of an increase in capillary hydrostatic pressure (when the intestine is naturally blood supplied), as decrease in the latter (when the preparation is perfused under constant inflow).

[The microhemodynamics and lymph flow in the small intestine under the action of histamine against a background of water loading and hyperthermia in dogs].

In anesthetized dogs, an increase of the lymph flow and the transcapillary fluid transfer, under the effect of histamine, was due to elevation of capillary hydrostatic pressure and capillary filtration coefficient in the small intestine. Against the background of water load and hyperthermia, histamine induced less obvious shifts of the microhemodynamic parameters and lymph flow in the small intestine.

[The dependence of changes in the microhemodynamics and lymph formation in the liver on the level of the arterial and portal blood flows].

In cats, when perfusing hemodynamically isolated liver with a constant blood volume, an increasing of arterial as well as portal blood flows was shown to increase hydrostatic pressure in sinusoids and lymph production in the liver, whereas decreasing of the flows decreased these parameters. The above changes of the blood flows entailed various shifts of sinusoidal hydrostatic pressure and postsinusoidal resistance. When the volume blood flow in the liver artery increased, the coefficient of sinusoidal filtration increased too, whereas an increment of the blood flow in portal vein led to its diminishing.

[Dependence of the parameters of microcirculation and lymph flow in the liver on the value of venous pressure].

In experiments on cats the perfusion (at a constant flow and controlled venous outflow) of haemodynamic isolated liver was carried out. It was shown that at the levels of venous pressure in the liver 0, 2, and 4 mm Hg, the lymph flow (22.8 +/- 3.

[The relation of lymph flow and microcirculation in the cat liver under the effect of serotonin and bradykinin].

In experiments on cats with hemodynamically isolated and perfused wider constant flow liver it was shown that intraarterial or intraportal infusion of serotonin and bradykinin increased a transinusoidal fluid fransher and lymph formation in the region. The elevated franshes walls of maintained mainly by an increase on the permeability of the walls of exchange microvessels. Differences were revealed in the achions of serofouri and bradykinin upon liver's arterial and portal vessels, the sensitivity of portal vein to the drugs being which lesser than of the live artery.