Publications by authors named "N V Kolupaeva"

Article Synopsis
  • The study investigates the virulence of two clinical strains of the Beijing genotype associated with drug-resistant tuberculosis in C57BL/6 mice, highlighting their correlation to global health issues.
  • Strains 267/47 (pre-XDR) and 120/26 (MDR) showed differing survival rates in infected mice, with 10% and 40% survival, respectively, compared to 70% for the H37Rv strain.
  • Comparison of immune responses revealed significant differences in cytokine gene expression, particularly with downregulated pro-inflammatory and anti-inflammatory genes in mice infected with the more virulent strain 267/47.
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Flannel flags (100 X 200 mm) were tested for fleas collection directly at the entrances of rodents' holes in the steppe region. The method proved to be most effective compared to some other wide-spread techniques. Flannel flags assured the highest number of insects collected during quantitative assessment of fleas' populations.

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Content of polyamines and some patterns of metabolism related to their synthesis and catabolism were studied in blood of patients with chronic myeloleukemia and chronic lympholeukemia. Free polyamines as well as activity of diamine oxidase were distinctly increased in blood, while concentration of total diamino acids was simultaneously decreased in blood serum of the patients as compared with that of healthy persons. Specific type of the quantitative alterations was responsible for efficiency of chemotherapy in these patients.

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