CLINICAL MANIFESTATION AND EPIDEMIOLOGICAL PECULIARITIES OF LEPTOSPIROSIS AT THE MODERN STAGE IN GEORGIA.

Introduction: Leptospirosis is considered one of the most common zoonotic infections in the world and is characterized by distribution in countries of subtropical and tropical zones. In Georgia A sharp increase in the frequency of leptospirosis began in 2011, and the morbidity rate increased to 16.3.

Possible link between familial susceptibility to cancer and the level of oxidative stress in thyroid cancer patients.

Background: Hereditary cancer is estimated to account for up to 10% of the worldwide cancer burden; 5% of all thyroid cancers are thought to be genetic. Inheritance of a deleterious mutation in genes associated with a high lifetime risk of developing cancer. Cancer-predisposing genes can promote the initiation and progression of thyroid cancer by enhancing the activation of major signaling pathways through oxidative stress mechanisms.

Comprehensive study of the rheological status and intensity of oxidative stress during the progression of type 2 diabetes mellitus to prevent its complications.

Background: Prevention of Type 2 diabetes mellitus (T2DM) requires a modifying effect on the pathological processes inducing the β-cell dysfunction.

Objectives: the comprehensive study of the violation of rheological parameters in patients with different stages of diabetes and identification of possible links between these alterations with the intensity of the oxidative stress in the patient's body.

Methods: 60 patients with IR, prediabetes, T2DM and healthy volunteers were included.

Some Aspects of Role of Nitric Oxide in the Mechanisms of Hypertension (Experimental Study).

Background: Modulation of endothelial function is a therapeutic option to reduce some of the significant complications of hypertension. However, the relationship between endothelial dysfunction reduced nitric oxide (NO) production, and the development of hypertension is not fully understood. To establish a potential pathogenetic link between impaired NO synthesis and hypertension, we investigated the results of competitive interaction of the substrate of NO synthase, L-arginine, and its analog, an non-selective inhibitor of NO synthase, N-nitro-methyl ether-L-arginine (L-NAME), in experimental rats.

NEW APPROACHES TO THE TREATMENT OF PERIIMPLANTITIS (REVIEW).

Implant therapy, a modern treatment option for completely and partially edentulous patients. However, numerous clinical studies indicate a sufficiently large number (9-20%) of the failure rate of implants. The achievement of osseointegration depends on many factors, such as a suitable host, alteration in bone metabolism, hormone balance, smoking habits, and local conditions (quantity and quality of bone, biocompatible materials, traumatic surgical technique, occlusal conditions, quality of dental implants, and corrosion of the metal of implants, thoroughness of surgery and healing time).