Publications by authors named "N V Khaidarova"
Dyslipidemia plays an essential role in chronic kidney disease (CKD). The role of lipids and lipoproteins in the early pre-disease state of CKD in hypertensive patients is still unclear. The study aimed to evaluate the relationship between early renal dysfunction and lipid profile parameters among hypertensive patients in Kazakhstan.
View Article and Find Full Text PDFTemplate activating factor-I (TAF-I) is a multifunctional protein involved in various biological processes including the inhibition of histone acetylation, DNA replication, cell cycle regulation, and oncogenesis. Two main TAF-I isoforms with different N-termini, TAF-Iα and TAF-Iβ (SET), are expressed in cells. There are numerous data about functional properties of TAF-Iβ, whereas the effects of TAF-Iα remain largely unexplored.
View Article and Find Full Text PDFArticle Synopsis
- The TRIM14 protein is involved in both antiviral defense and cancer processes, affecting apoptosis in different ways depending on the type of tumor cells.
- A study investigated the role of human TRIM14 and its mutant form in inducing apoptosis in transgenic loach embryos, revealing increased apoptosis associated with both forms of the gene.
- The findings suggest that TRIM14 promotes cell death during embryonic development through the activation of certain proapoptotic genes, with the mutant version following a different, p53-independent pathway.
In the present research, we have studied an influence of enhanced expression TRIM14 on alphavirus Sindbis (SINV, Togaviridae family) infection. In the HEK293 cells transfected with human trim14 gene (HEK-trim14), SINV yield after infection was decreased 1000-10,000 times (3-4 lg of TCD50/ml) at 24 h p.i.
View Article and Find Full Text PDFThe trim14 (pub, KIAA0129) gene encodes the TRIM14 protein which is a member of the tripartite motif (TRIM) family. Previously, we revealed high expression levels of trim14 in HIV- or SIV-associated lymphomas and demonstrated the influence of trim14 on mesodermal differentiation of mouse embryonic stem cells (mESC). In the present work, to elucidate the role of trim14 in normal and pathological processes in the cell, we used two different types of cells transfected with trim14: mESC and human HEK293.
View Article and Find Full Text PDF