[Magnesium deficiency and dysregulation of vascular tone].

Magnesium deficiency is associated with impaired vascular tone bidirectionally and can lead to both an abnormal increase and abnormal lowering of blood pressure. This article analyzes studies on the relationship between blood pressure parameters and the level of magnesium in the blood. Evidence base for the use of magnesium for correction of vascular tone is presented.

[Antiproliferative effect of polar lipids of maral antlers and peat in prostate benign hyperplasia model].

Lipids isolated from maral antlers and peat decreased the prostate posterior and lateral lobule mass and normalized its acinar and stromal histological structure, reduced protein content, decreased formation of lipid peroxidation products, and intensified antioxidant protection in homogenates, decreased prolactine and 5a-dihydrotestosterone blood level, and increased testosterone blood content in male rats of late reproductive age with prostate benign hyperplasia model caused by sulpiride injections. Polar lipids of maral antlers and peat more effectively suppress prostate hyperplasia and hyperprolactinemia development in comparison to the action of Serenoa repens extract (permixon).

[Potassium-preserving properties of magnesium].

Current fundamental research indicates importance of conducting clinical studies of the influence of magnesium content of the body on the potassium homeostasis. In this work we systematically analyze molecular mechanisms through which magnesium regulates potassium homeostasis: ATP-sensitive inward rectifier K-channels, Na+/K(+)-ATPases and their regulatory protein SIK1, transporter SLC12A3 and WNK-kinases. Hyperkalemia as well as hypokalemia require safe and effective prevention and therapy, including restoration of magnesium homeostasis.

[Gastroprotective action of the nettle extract in experimental peptic ulcer].

Nettle extract produced from leaves crushed to 40-70 nm fragments protects the stomach mucous membrane, and does it better than the extract derived from same leaves crushed to 1 mm fragments, on the models of peptic ulcers caused by acetylsalicylic acid, histamine, prednisolone, and immobilized stress. The antiulcer activity of the nettle extract from 40-70 nm fragments is comparable with the effect of buckthorn oil. Nettle extracts also hinder the excess acid secretion and diminish the acidity of stomach juice in experimental peptic ulcer caused by pylorus ligation.

[Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia].

Aim: To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children.

Subjects And Methods: A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008.

Results: With the median observation of 4.