[The role of PPARs and their isoforms in metabolic disorders related to insulin resistance and diabetes].

PPARs play the key role in energy homeostasis, inflammation, development of insulin resistance, metabolic syndrome, therefore the special attention is spared to synthesis of the ligand PPARs (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by the fatty acids and their derivatives - eukosanoides. Polymorphism of the Pro 12Ala gene PPARG2 affects the sensitiveness of tissues to insulin and the risk of the development diabetes.

[Regulation of endothelial NO-synthase expression and vascular endothelium dysfunction in cardiovascular pathology].

Nitric oxide (NO) is synthesized from 1-arginine by endothelial nitric oxide synthase (eNOS). NO participates in regulation of physiologically important cardiovascular functions (contractive reduction of heart, cellular proliferation, a tone of vessels and blood pressure), immunity, and nervous systems. Inflammation factors, hypoxia, lipids affect NO synthesis.

[The effect of hypothermia on the Ca2+-pump in sarcoplasmatic reticulum during autolysis of the myocardium].

Certain hypothermia action mechanisms on Ca2(+)-pump of the sarcoplasmic reticulum in rat myocardium autolysis are investigated. The complex dependence of Ca2(+)-transporting system preservation in autolysis on the depth of hypothermia is shown. The role of lipid peroxidation and endoproteolysis in a decrease of the autolysing myocardium Ca2(+)-pump activity is considered.