[The effectiveness of fractionated exposure of sarcoma M-1 to gamma-radiation and fast neutrons].

The effectiveness of fractionated exposure to gamma- and neutron radiation in their separate and combined use on the growth and functional morphology of mutant p53 sarcoma M-1 in rats was studied. Investigation techniques included immunostaining of PCNA and mutant p53 expressing cells, determination of mitotic activity and apoptotic death of tumor cells, as well as computer analysis of microscopic images. The antitumor efficacy of different types of radiation is shown to be determined by different levels of apoptosis induction, reduced proliferation and cellularity.

[Phlebotrophic therapy with venarus in patients suffering from lower limb chronic venous insufficiency].

The article deals with medicamentous therapy of lower limb chronic venous insufficiency (LLCVI). The authors analysed herein the results of treating patients suffering from LLCVI using Venarus whose basic components are diosmin and hesperidin. The obtained findings demonstrated that clinical administration of this phlebotonic agent is effective in the given cohort of patients during the whole therapeutic course, with a maximum positive effect observed within the first 4 weeks.

[Successful treatment of bradyarrhythmia associated with obstructive sleep apnea syndrome by continuous positive airway pressure].

Obstructive Sleep Apnea Syndrome (OSAS) is an additional independent factor of growth of cardiovascular mortality. Special role disturbances of respiration during sleep play in development of nocturnal cardiac arrhythmias. Approaches to correction of OSAS associated nocturnal bradyarrhythmias have substantially changed during recent years.

[Corneal ulcer caused by Serratia marcescens: case report].

A case of corneal ulcer caused by Serratia marcescens is reported in a patient with history of corneal microtrauma. Biological features (pathogenicity factors, antibiotic resistance) of isolated culture were characterized. Keratitis cases caused by this agent were analyzed.

[Peculiarities of professional burnout of anaesthetists-experts in resuscitation in various age periods].

The article is devoted to consideration of the problem of professional burnout with anaesthetists-experts in resuscitation in various age periods that is very actual in modern medicine. It is shown that peculiarity of the doctors' activity provokes formation of professional burnout in them. Psycho-emotional tension born by the sense of responsibility before the patients determines formation of responsible attitude of the doctors towards therapy, but it also has negative consequences in concern with disorder of homeostatic balance and unreasonable energetic expenditure.