[Substantion of the reference Values of SCFA in saliva in ratients without upper respiratory tract diseases.].

Biochemical indicators of saliva were studied in 47 patients of the intensive care unit and intensive care unit of a neurosurgical hospital with varying degrees of severity of the disease. The method of gas-liquid chromatography of the acidified substrate of the saliva filtrate determined the concentrations of short-chain fatty acids (SCFA) and their reference values for patients without respiratory tract diseases. The threshold values of the concentrations of SCFA and the values of their calculated indices were determined by ROC analysis with the construction of the ROC curve, calculation of the area under the curve (AUC) and the cutoff threshold CutOff.

[THE EVALUATION OF MICROBIOLOGICAL DISORDERS OF MICROFLORA OF OROPHARYNX AND INTESTINE USING MATHEMATICAL MODELING TECHNIQUE].

The analysis was applied to microflora of feces and oropharinx and concentration of volatile fatty acids in saliva from patients of consultative diagnostic center of G.N. Gabrichevskii Moscow research institute of epidemiology and microbiology.

[Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].

The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivirals in the MDCK cells culture demonstrated that Arbidol, Rimantadine and Ribavirin efficiently inhibited reproduction of the highly pathogenic H5N1 influenza viruses isolated from sick birds. Arbidol and Oseltamivir carboxylate selectively inhibited reproduction of the pandemic 2009 H1N1 influenza A viruses with changed specificity to the cell receptors, causing severe influenza in men, while remantadine had no effect on their reproduction.

[Study of the antiviral activity of Russian anti-influenza agents in cell culture and animal models].

The study of the antiviral activity of Russian anti-influenza agents in the cultured MDCK cells demonstrated that arbidol and ribavirin inhibited the reproduction of various influenza A virus strains, including rimantadine- and ozeltamivir-resistant variants, as well as influenza B viruses (IC50 2-8.5 microg/ml). Rimantadine at concentrations of 1-5 microg/ml completely inhibited the reproduction of reference and ozeltamivir-resistant influenza A virus strains, and it had no effect on the reproduction of influenza B viruses and rimantadine-resistant influenza A viruses.