Recently revised brain tumor classification suggested a glioma treatment strategy that takes into consideration molecular variants in and marker genes. While pathogenic variants of IDH1 and TP53 can be accompanied by chromosomal instability (CIN), the impact of and mutations on genome stability remains unstudied. Elevated CIN might provide therapeutic targets, based on synergistic effects of chemotherapy with CIN-inducing drugs.
View Article and Find Full Text PDFCentromeres are crucial for chromosome segregation but are vulnerable to breakage and recombination due to their repetitive DNA. The mechanisms protecting centromeres from these instabilities remain incompletely understood. This study investigates the role of the homologous recombination (HR) mediators BRCA2 and PALB2 in centromere stability.
View Article and Find Full Text PDFVavilovskii Zhurnal Genet Selektsii
November 2024
Synthetic intergeneric amphydiploids and genome-substituted wheat forms are an important source for transferring agronomically valuable genes from wild species into the common wheat (Triticum aestivum L.) genome. They can be used both in academic research and for breeding purposes as an original material for developing wheat-alien addition and substitution lines followed by translocation induction with the aid of irradiation or nonhomologous chromosome pairing.
View Article and Find Full Text PDFAlbumin is a major protein in mammalian blood plasma or serum, where its concentration in healthy organisms is about 600 μM [...
View Article and Find Full Text PDFData are accumulating on the hydrolytic activity of serum albumin towards esters and organophosphates. Previously, with the help of the technology of proton nuclear magnetic resonance (H NMR) spectroscopy, we observed the yield of acetate in the solution of bovine serum albumin and -nitrophenyl acetate (NPA). Thus, we showed that albumin possesses true esterase activity towards NPA.
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