Use of recombinant alpha-2b-interferon in combination with antioxidants in the form of rectal suppositories (viferon) in children with chronic hepatitides B and C.

A new antiviral and immunomodulating preparation Viferon, produced as rectal suppositories containing recombinant alpha-2b-interferon (IFN) and antioxidants, was used in complex therapy of viral chronic hepatitides B and C (ChHB and ChHC) in children. Results of our investigation showed a high efficiency of Viferon. Viferon was found to suppress replication of hepatotropic viruses and to decrease activity of the pathologic process in the liver of children with ChHB and ChHC.

[Human blood biochemical parameters under the conditions of an arid zone].

Seven participants of 23 day walking march in an arid environment have been examined. Biochemical analysis of blood serum made on Day 2 of marching revealed a decrease in the levels of glucose, triglycerides and an increase in the concentration of non-esterified fatty acids which the authors characterize as the state of moderate stress in an acute period.

[Lipid peroxidation and the system of antioxidant protection in rats following a 13-day space flight on the Kosmos-1887 biosatellite].

After a 13-day space mission, in the rats flown on Cosmos-1887 biosatellite the parameters of lipid peroxidation and antioxidant defense system--the contents of diene conjugates, malonic dialdehyde, Schiff bases, tocopherol, total antioxidant activity (in blood plasma only), antioxidant enzyme activity (in tissues only)--superoxide dismutase, catalase, glutathio peroxidase, glutathio reductase have been measured in the blood plasma, myocardium, skeletal muscles and liver. The liver level of diene conjugates, Schiff bases and tocopherol decreased, and an activity of superoxide dismutase and catalase increased. In the skeletal muscles there was an elevation of diene conjugate contents followed by the decreases in malonic dialdehyde and superoxide dismutase activity.

[Effect of long-term space flight on erythrocyte metabolism and the function of the erythrocyte membrane].

This paper presents the data about red blood cell metabolism and the structure and function of erythrocyte membranes obtained from two cosmonauts after their 326- and 160-day flights. In both cases we observed inhibition of energy formation (decrease of the rate of glycolysis and ATP content) and enhancement of oxidative processes (decrease of reduced glutathione and activity of antioxidative enzymes). The above changes in the metabolic status of erythrocytes are correlated with shifts at the membrane level, particularly with variations of membrane lipids, phospholipid spectrum and ratios of phospholipid fractions, alteration of membrane-bound enzymes (ATPase) and increase of cell resistance to acid hemolysis.

[Status of the lipid peroxidation system in the tissues of rats following a 7-day flight on the Kosmos-1667 biosatellite].

Rats flown for 7 days on Cosmos-1667 were for the first time used to measure antioxidative enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase), lipid peroxidation products (diene conjugates, malonic dialdehyde, Schiff bases) and tocopherol. Enhanced lipid peroxidation in the heart was completely compensated by activation of antioxidative enzymes. The content of all lipid peroxidation products measured in the liver increased; this was accompanied by a decrease of glutathione peroxidase and an increase of superoxide dismutase activities.