Publications by authors named "N V Carobin"
Article Synopsis
- - Brazil experienced significant COVID-19 impact, highlighted by high death tolls and four main peaks of cases, with the last two waves driven by the emergence of the Omicron variant and its sublineages BA.1, BA.2, BA.4, and BA.5.
- - A study analyzed virus samples from 15 health units in Minas Gerais, revealing that BA.1 and BA.2 were most common in the third wave, while BA.4 and BA.5 dominated the fourth.
- - Findings indicate that vaccination, especially booster doses, played a crucial role in reducing deaths, and the study confirmed the introduction of Omicron subvariants through multiple international cases with continued local transmission.
Article Synopsis
- - Sewage surveillance is a useful method for detecting viruses in local communities and can help track outbreaks and emerging health threats, as demonstrated in Belo Horizonte, Brazil through the detection of the Mpox virus in wastewater samples over 9 months.
- - The study found varied detection rates of MPXV DNA, with higher rates in hospital wastewater (40%) compared to municipal wastewater (13.3%), likely influenced by the low number of reported MPXV cases and dilution from large populations served by wastewater treatment plants.
- - In addition to MPXV, nine other virus families were identified, including SARS-CoV-2, highlighting the potential of genomic sewage surveillance as a key public health tool for monitoring diverse viral activity in both hospital and community settings
It has been shown that AMP-activated protein kinase (AMPK) is involved in the nociceptive processing. This observation has prompted us to investigate the effects of the AMPK activator metformin on the paclitaxel-induced mechanical allodynia, a well-established model of neuropathic pain. Mechanical allodynia was induced by four intraperitoneal (i.
View Article and Find Full Text PDFMonitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study.
Viruses
December 2022
Article Synopsis
- The Gamma variant of COVID-19, first identified in Brazil, has been linked to higher infection rates, hospitalizations, and fatalities, especially during a surge in Minas Gerais in March-April 2021.
- A surveillance study analyzed 1,240 COVID-19-positive samples across 305 municipalities, finding that Gamma was the most prevalent variant (71.2%), followed by Zeta (12.4%) and Alpha (9.6%).
- The study emphasizes the necessity of vaccination to mitigate severe cases and deaths, noting no significant mortality differences among the different variants identified.
Severe cases of COVID-19 present hyperinflammatory condition that can be fatal. Little is known about the role of regulatory responses in SARS-CoV-2 infection. In this study, we evaluated the phenotype of regulatory T cells in the blood (peripheral blood mononuclear cell) and the lungs (broncho-alveolar) of adult patients with severe COVID-19 under invasive mechanical ventilation.
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