Publications by authors named "N V Bogdanova"
Background And Aims: Cadherins are adhesion proteins, and their dysregulation may result in the development of atherosclerosis, plaque rupture, or lesions of the vascular wall. The aim of the present study was to detect the associations of cadherins-P, -E, and -H, with atherosclerosis and pathological cardiovascular conditions.
Methods And Results: The present study with 3-year follow up evaluated atherosclerosis and fasting levels of P-, E-, and H-cadherins in the serum samples of 214 patients in a hospital setting.
Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.
Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.
Article Synopsis
- * Results show that offspring of intoxicated fathers have significantly reduced motor activity and altered anxiety-like and depressive-like behaviors.
- * The findings suggest that alcohol consumption by males may affect gene methylation in offspring, leading to changes in enzyme activity and neuropeptide balance that influence behavior.
: Placental cadherin (CDH3) is an adhesion molecule expressed in many malignant tumors. The role of serum CDH3 in atherosclerosis is unclear. : This 3-year follow-up study measured atherosclerosis and serum CDH3 in 218 angiography inpatients.
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- * A study involving 342 endometrial cancer patients and 178 breast cancer patients from Almaty, Kazakhstan found 2.9% of endometrial cases carried pathogenic MMR variants, while 4.1% had HDR variants.
- * In the breast cancer group, 4.5% had MMR variants and 6.7% had HDR variants, indicating that these gene variants are common in both types of cancer within the Kazakh population.