THE MODIFYING ROLE OF TOXIC SUBSTANCES ON GENOTOXIC EFFECT IN THE BODY DURING COMBINED ADMINISTRATION WITH CARCINOGEN (BENZO[A]PYRENE).

Objective: The aim: of this work was to experimentally study the modifying role of toxic substances (phenol) in the manifestation of genotoxic and immunological changes in the body when exposed to a carcinogen (benzo[a]pyrene).

Patients And Methods: Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice. Genotoxic (micronucleus test), immunologic and pathomorphological methods were used.

On the issue of accelerated hygienic assessment of environmental genotoxic carcinogens.

Objective: The aim of the work was assessment of the criterial significance of the complex of early immunological reactions of the organism, pathomorphological and genotoxic changes in the organs for the acceleration of testing and hygienic assessment of carcinogenic danger of chemical substances.

Patients And Methods: Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice and included 2 series of the investigations: 1 - application of benz(a)pyrene on skin in different doses (10.5µg; 2.

[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].

The paper presents the results of studying the carcinogenic effect of chloroform and its combination with carbon tetrachloride, 1,2-dichloroethane, trichloroethylene during chronic oral administration to F1(CBAxC57Bl6) mice. There is a relationship between the manifestation of carcinogenesis to the dose of chloroform and a combination of chemicals, as well as its enhancement upon exposure to the combination as compared with acute administration of chloroform. Exposure to a combination of substances at the level of their maximum permissible concentrations does not affect carcinogenesis.

[Setting normal levels of benz(a)pyrene in foods].

In the paper, methodological requirements are formulated for validation of permissible levels of benz(a)pyrene (B(a)P) in foodstuffs. A list is submitted of allowable levels of this carcinogen in food products for the population of Ukraine, their specific values being dependent on the accepted tolerance daily done intake and on the structure of the standard food ration. Prevention of B(a)P formation and its elimination from the human habitat together with the use of the modern environmentally appropriate technologies designed to prepare food products will form a basis for stabilization of the permissible dose of the carcinogen, finding its way to the human body as a food component through dietary intake.