Publications by authors named "N V Adsay"
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms that include tumors with different histomorphologic characteristics that can be correlated to sub-categories with different prognoses. In addition to the WHO grading scheme based on tumor proliferative activity, a new parameter based on the scoring of infiltration patterns at the interface of tumor and non-neoplastic parenchyma (tumor-NNP interface) has recently been proposed for PanNET categorization. Despite the known correlations, these categorizations can still be problematic due to the need for human judgment, which may involve intra- and inter-observer variability.
View Article and Find Full Text PDFInactivating alterations in the SWItch/Sucrose NonFermentable (SWI/SNF) Chromatin Remodeling Complex subunits have been described in multiple tumor types. Recent studies focused on SMARC subunits of this complex to understand their relationship with tumor characteristics and therapeutic opportunities. To date, pancreatic cancer with these alterations has not been well studied, although isolated cases of undifferentiated carcinomas have been reported.
View Article and Find Full Text PDFArticle Synopsis
- A study analyzed 69 pancreatic intraductal papillary neoplasms (IPNs) and various related samples, identifying over 10,000 proteins and 22,000 glycopeptides using mass spectrometry.
- *Among these, 756 proteins showed increased abundance in IPNs compared to normal pancreatic ducts, with 45% also found in cyst fluids.
- *The research also distinguished two subtypes of IPMs and highlighted potential targets for earlier detection and treatment of pancreatic cancer.*
Background: Grade 1/2 PanNETs are mostly managed similarly, typically without any adjunct treatment with the belief that their overall metastasis rate is low. In oncology literature, Ki67-index of 10% is increasingly being used as the cutoff in stratifying patients to different protocols, although there are no systematic pathology-based studies supporting this approach.
Methods: Ki67-index was correlated with clinicopathologic parameters in 190 resected PanNETs.