Barrier Factors of Adherence to Dupilumab Self-Injection for Severe Allergic Disease: A Non-Interventional Open-Label Study.

Purpose: The status of dupilumab self-injection at home is not well understood. We therefore aimed to identify the barriers to adherence to dupilumab self-injection.

Patients And Methods: This non-interventional open-label study was conducted between March 2021 and July 2021.

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Very Short-term Use of Proton Pump Inhibitor.

Proton pump inhibitors (PPIs) are widely used medicines worldwide. However, a rare etiology of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) related to PPI was recently reported. Therefore, the putative role of PPIs in SIADH cannot be underestimated.

Full-range, complex spatial light modulator for real-time holography.

We demonstrate a full-range complex and transmissive spatial light modulator (SLM) for simultaneous and independent amplitude and phase modulation of an input wave field. Arbitrary scalar complex optical fields are generated by stacking a pixelated liquid crystal display operating in phase-only (2π) modulation with passive polarization-sensitive components. The principle is based on optical combining the light fields of two neighboring phase-only modulating pixels, which were made orthogonally polarized by a structured half-wave plate, then passing through a birefringent plate to laterally shift one of the beams collinear to the other, and finally bringing to interference by a linear polarizer.

Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas.

The mechanism of disopyramide-induced hypoglycemia, a life-threatening complication in the antiarrhythmic drug treatment, is still controversial. To elucidate this, we have evaluated plasma insulin (IRI) and glucagon (IRG) responses in the pancreatic vein (PV) of the in situ pancreas as well as responses of plasma IRI, IRG, and glucose in the femoral artery (FA) to disopyramide phosphate administration in anesthetized dogs. First, infusion of disopyramide at a dose of 50 mg for ten minutes directly into the pancreatic artery, but not the vehicle, increased significantly plasma IRI concentration in the PV (P less than .

Pancreatic vagal nerve is receptive to somatostatin in rats.

To investigate whether somatostatin, one of the pancreatic islet hormones, influences the afferent firing activity of the vagus innervating the pancreas and whether there is any relevant morphological basis for the electrophysiological event, cyclic somatostatin-14 was injected into the rat pancreatic artery. The somatostatin injection at a physiological (0.61 pmol) or a pharmacological (3.