Publications by authors named "N Uragami"
Article Synopsis
- The MANTIS Clip is a new medical device designed to improve tissue grasping and close defects in the gastrointestinal tract, specifically after colorectal endoscopic submucosal dissection (C-ESD).
- A study at a single center from May 2023 to April 2024 involved 52 patients, showing a very high complete closure success rate of 98.1% and a sustained closure rate of 96.1% for mucosal defects.
- The procedure had minimal complications, with only one instance each of bleeding and coagulation syndrome, indicating the MANTIS Clip's effectiveness and practicality, but further multicenter trials are recommended for more comprehensive evaluation.
Mucosal defect closure after colorectal endoscopic submucosal dissection (ESD) has the potential to reduce the occurrence of delayed adverse events (AEs) such as bleeding and perforation. This study aimed to assess the feasibility and effectiveness of the Loop9 method for closing mucosal defects following colorectal ESD. A retrospective single-center study was conducted using prospectively collected data from May 2020 to March 2023.
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- - The study assessed the effectiveness of the endoscopic pressure study integrated system (EPSIS) to evaluate anorectal function in older and younger patients, hypothesizing that it could help diagnose lower gastrointestinal disorders.
- - A retrospective analysis of 30 patients showed significant differences in maximum rectal pressure measurements, with older patients (≥80 years) exhibiting lower pressure compared to younger patients (<80 years), indicating a decline in anorectal function with age.
- - The findings suggest that EPSIS could be a useful tool for understanding age-related changes in anorectal physiology, recommending that future research explores its potential in routine screenings and diagnosing anorectal issues.
Article Synopsis
- A study was conducted using Raman spectroscopy (RS) to detect cancer in unstained esophageal and gastric tissue specimens post-surgery, demonstrating that histological differences affect the Raman-scattered light spectrum.
- The researchers developed a Raman device for live tissue observation, successfully capturing spectra from 6 esophageal and 12 gastric samples without damaging the tissues.
- The results led to the establishment of diagnostic cut-off values and an algorithm for identifying esophageal squamous cell carcinoma and gastric adenocarcinoma based on molecular-level data analysis.
Article Synopsis
- Image-enhanced magnifying endoscopy improves the detection and diagnosis of gastrointestinal lesions, but existing classifications can confuse general gastroenterologists.
- The Unified Magnifying Endoscopic Classification (UMEC) was developed to be a simpler, organ-agnostic system that categorizes lesions into non-neoplasia, intramucosal neoplasia, and deep submucosal invasive cancer.
- In a feasibility pilot study, two experienced endoscopists evaluated 303 lesions using UMEC, achieving high diagnostic accuracy (approximately 84-89%) and good agreement between observers, suggesting UMEC's practicality and effectiveness for general use.