[Experimental research on the toxicity of pharmapentoxifylline (I)].

Results from the study on acute, subacute and chronic toxicity of the therapeutic preparation pharmapentoxiphyline (PP), produced by Pharmachem, are described. The experiments were carried out on 312 male and female white rats. According to the limiting index of LD50 with, Oral dose of (1220 mg/kg of body mass for male rats and 1050 mg/kg for female rats) and intraperitoneal PP dose of PP (230 mg/kg for female rats and 235 mg/kg for female rats) it was included into IV class of slightly toxic compounds.

[Thrombokinetic study of patients with idiopathic thrombocytopenic purpura].

The kinetics of 111In-oxine-labeled platelets was studied in 37 patients with idiopathic thrombocytopenic purpura and in 12 control subjects using gamma-chamber. A comparison was made of the parameters of the kinetics, survival and sequestration type of platelets, as well as their recovery and exchange. In less severe processes the splenic type, while in more severe disease--the hepatic type of sequestration prevailed.

[Thrombocyte kinetics in patients with thrombocytopenia].

Investigation of the kinetics of blood platelets is of paramount importance in cases where it is necessary to differentiate the cause of thrombocytopenia in patients: reduction of the output, changes in organ distribution or increase of sequestration of blood platelets. Using the method of labeling own blood platelets and a gamma-chamber, the kinetics of blood platelets (organ distribution, recovery and survival) was studied and computed in 40 patients with hypoplastic anemia, hypersplenism and thrombocytopenic purpura. A complex of the parameters characterizing the given disease has been defined.

[Scintigraphic imaging of the bone marrow in hematologic diseases].

The scintigraphy of the bone marrow can supply information for its distribution in the body and for its functional state as well. The purpose of the study is to assess the efficacy of the scintigraphic imaging of the bone marrow by means of radiopharmaceutical drugs--99mTc-sulfur colloid for imaging the monocytic macrophagal system and 111In-chloride for imaging of erythroid cells--and to determine its characteristics in some hematologic diseases. 72 patients with hematologic diseases and 10 healthy controls were examined.