Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese.

Objective: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent.

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese.

Background: Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is located (19p13.2).

Smoking cessation and glycaemic control in type 2 diabetic patients.

Aim: To elucidate the relationship between glycaemic control, blood pressure and body-weight change after smoking cessation in type 2 diabetic patients.

Methods: We examined HbA(1c), blood pressure and body weight in 15 type 2 diabetic patients before, 6 and 12 months after quitting smoking. Sixteen type 2 diabetic patients who did not quit smoking served as control.

A prospective pancreatographic study of the prevalence of pancreatic carcinoma in patients with diabetes mellitus.

Background: The correlation between diabetes mellitus and pancreatic carcinoma is well documented, but no criteria have been established for the efficient selection of a high-risk group among patients with diabetes mellitus.

Methods: Eighty-seven patients were selected prospectively from outpatients with diabetes and underwent endoscopic retrograde pancreatography (ERP) according to the authors' original criteria, including the onset of diabetes after age 55 years, deterioration of diabetes or loss of body weight despite strict medical control, elevation of serum amylase and/or CA19-9 levels, and pancreatobiliary abnormalities on routine ultrasonography. The patients were divided into two groups according to the time from the onset of diabetes to ERP: Patients in Group A had recent-onset diabetes (within 3 years), and Group B patients had diabetes for > 3 years.

Background factors correlated with the psychological features of 254 outpatients with Type 2 diabetes mellitus in Japan.

Unlabelled: For the purpose of identifying the features of psychological troubles and their significance in Type 2 diabetes mellitus outpatients, we analyzed how psychological troubles were affected by various background factors. SUBJECTS AND METHODS The subjects all consisted of outpatients > or = 40 years of age at the Fukuoka Red Cross Hospital in December 1996. We used the State-Trait Anxiety Inventory (STAI) to determine anxiety, the Self rating Depression Scale to determine depression.