Publications by authors named "N Tsuruta"
Article Synopsis
- Clinical trials often leave out elderly patients, leading to limited safety and efficacy data for biologics in this demographic.
- A study comparing elderly (≥65 years) and younger (<65 years) patients using data from the West Japan Psoriasis Registry found that treatment-ending adverse events were more common in the elderly, and malignant neoplasms occurred at higher rates.
- Despite some safety concerns, biologics were effective for both age groups, with no significant differences in treatment outcomes or quality of life indicators between the elderly and younger patients.
Article Synopsis
- Systemic treatments for moderate-to-severe psoriasis can lead to cutaneous infections, although the specific risks of these infections are not well documented.
- In a study involving 878 psoriasis patients treated with biologics, the incidence of cutaneous bacterial, viral, and fungal infections was analyzed, revealing low but significant rates for each type.
- The findings indicated that specific treatments, such as tumor necrosis factor-α and interleukin-17 inhibitors, are linked to higher risks of bacterial and fungal infections, respectively, highlighting the need for careful monitoring by dermatologists.
Recent practice guidelines strongly recommend evidence-based psychotherapies (EBPs) as the first-line treatment for post-traumatic stress disorder (PTSD). However, previous studies found barriers to the implementation of EBPs and a relatively high dropout rate in clinical settings. After proving the efficacy of prolonged exposure (PE) in Japan [Asukai, N.
View Article and Find Full Text PDFThe cancer stem cell (CSC) theory features typically rare self-renewing subpopulations that reconstitute the heterogeneous tumor. Identification of molecules that characterize the features of CSCs is a key imperative for further understanding tumor heterogeneity and for the development of novel therapeutic strategies. However, the use of conventional markers of CSCs is still insufficient for the isolation of bona fide CSCs.
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