[7-Chloro(phenylthio)-4-phenylaminoquinolines. Study of its anti-inflammatory and analgesic activity].

Some 7-chloro(phenylthio)-4-phenylaminoquinolines substituted in the benzene rings were prepared and subject to the Winter test for potential antiinflammatory activity and the acetic acid test for analgesic activity. Derivative (I) was devoid of antiinflammatory properties but showed interesting analgesic activity although this was 30 times weaker than that of indomethacin used as reference substance. The DL50/DE50 ratio is greater than 16 for derivative (I) and 3 for indomethacin.

[Perfusion of isolated rat liver. Utilization of a perfusion without heparin. Validity of the preparation].

The blood and liver giver animals are given "Tromexan" for a period of three days. The blood defibrination is finished off by shaking. The perfusion is made of defibrinated blood to which is added a compounding of mineral salts, albumin and glucose in adequate proportions.

[Metabolic study of 3 fat emulsions for intravenous nutrition. II. Study by isolated rat liver perfusion].

With a model of isolated rat liver perfusion, the authors study the removal kinetic of three different fat emulsions. In experiments done with Lipiphysan, triglyceride uptake by liver is linear with a rate of 30 mg/h until the 60th minute; after blockade of the reticuloendothelial system (RES), triglyceride uptake is greatly reduced. In standard experiments done with Intralipid and Trive 1000, triglyceride content of the perfusate does not vary significantly; however, the study of free fatty acids removal done before and after liberation of hepatic triglyceride lipase by heparin seems to show that Intralipid triglycerides are slightly hydrolyzed by hepatic triglyceride lipase.

[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].

Hypothermia inhibits the (Na+ K+) ATPase but does not decrease the concentrations of Na in bile when NaCl is added to the perfusate. With ouabaïne, another inhibitor of (Na+ K+) ATPase, we had previously seen decrease of sodium excretion. This discrepancy might be the result of an increase excretion in bile acids during hypothermia.