Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report.

Background: Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include dosing errors, metabolic syndrome, hypoalbuminemia, renal dysfunction, lack of folate supplementation, and the concomitant use of drugs that interfere with methotrexate metabolism. Vitamin B12 deficiency leads to megaloblastic anemia and may cause pancytopenia, but its role in methotrexate toxicity has not been described.

Factors Associated With Use of Nonoral Nutrition and Hydration Support in Adult Patients With Postural Tachycardia Syndrome.

Background: Patients with postural tachycardia syndrome (POTS) often have gastrointestinal (GI) symptoms. Occasionally, these symptoms can be so severe that nonoral nutrition/hydration support (NONHS), including intravenous fluids (IVFs), enteral nutrition (EN), and parenteral nutrition (PN), becomes necessary.

Methods: This is a retrospective cohort study of adult patients diagnosed with POTS at the Mayo Clinic Arizona from January 2010 to January 2017 with a minimum of 6 months of follow up.

Mesocestoides sp. in Wild Northern Bobwhite ( Colinus virginianus) and Scaled Quail ( Callipepla squamata).

Mesocestoides spp. have a cosmopolitan distribution with zoonotic potential. Mesocestoides tetrathyridia were found under the pericardial sac, on the surface of the crop, and in the peritoneal cavity of a hunter-harvested Northern Bobwhite ( Colinus virginianus) and a Scaled Quail ( Callipepla squamata) collected during the 2016-17 quail hunting season in northwest and southern Texas, US respectively.

Estimating the impact of adopting the revised United Kingdom acetaminophen treatment nomogram in the U.S. population.

Background: Acetaminophen toxicity is common in clinical practice. In recent years, several European countries have lowered the treatment threshold, which has resulted in increased number of patients being treated at a questionable clinical benefit.

Objective: The primary objective of this study is to estimate the cost and associated burden to the United States (U.

Helminth community structure in two species of arctic-breeding waterfowl.

Climate change is occurring rapidly at high latitudes, and subsequent changes in parasite communities may have implications for hosts including wildlife and humans. Waterfowl, in particular, harbor numerous parasites and may facilitate parasite movement across broad geographic areas due to migratory movements. However, little is known about helminth community structure of waterfowl at northern latitudes.