Publications by authors named "N Traber-Walker"
Article Synopsis
- The clinical high-risk (CHR) state for psychosis shows a lot of variability among individuals, causing challenges in treatment and research, especially since basic symptoms have often been overlooked.
- The study assessed 875 patients from early intervention centers in Germany and Switzerland, using specific diagnostic tools to categorize their symptoms and demographics.
- Results led to identifying three distinct clinical profiles: one with low symptom probability and high functioning, another with high basic and positive symptoms but low functioning, and a third mainly showing attenuated hallucinations, which can guide targeted interventions in future care.
Background: In children and adolescents compared to adults, clinical high-risk of psychosis (CHR) criteria and symptoms are more prevalent but less psychosis-predictive and less clinically relevant. Based on high rates of non-converters to psychosis, especially in children and adolescents, it was suggested that CHR criteria were: (1) Pluripotential; (2) A transdiagnostic risk factor; and (3) Simply a severity marker of mental disorders rather than specifically psychosis-predictive. If any of these three alternative explanatory models were true, their prevalence should differ between persons with and without mental disorders, and their severity should be associated with functional impairment as a measure of severity.
View Article and Find Full Text PDFImportance: Diverse models have been developed to predict psychosis in patients with clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining clinical and biological models and by broadening the risk spectrum to young patients with depressive syndromes remains unclear.
Objectives: To evaluate whether psychosis transition can be predicted in patients with CHR or recent-onset depression (ROD) using multimodal machine learning that optimally integrates clinical and neurocognitive data, structural magnetic resonance imaging (sMRI), and polygenic risk scores (PRS) for schizophrenia; to assess models' geographic generalizability; to test and integrate clinicians' predictions; and to maximize clinical utility by building a sequential prognostic system.
Schizophrenia is a complex and chronic neuropsychiatric disorder, with a heritability of around 60-80%. Large (>100 kb) rare (<1%) copy number variants (CNVs) occur more frequently in schizophrenia patients compared to controls. Currently, there are no studies reporting genome-wide CNVs in clinical high risk for psychosis (CHR-P) individuals.
View Article and Find Full Text PDFArticle Synopsis
- * The study protocol includes a treatment program called "Robin," which combines therapy modules with a smartphone app to support the mental health of CHR adolescents aged 14-18.
- * This trial aims to evaluate the effectiveness of the Robin approach by comparing it to standard treatment, with outcomes assessed at multiple time points over 3 years, marking it as a pioneering effort in early intervention for psychosis in adolescents.