Publications by authors named "N Touil"
Background: This study aimed to evaluate the immunogenicity of a two-dose Sinopharm BBIB-CorV (Vero cells) vaccine against SARS-CoV-2, at 28 days, 6 months, and 1-year postvaccination. And assess the capacity of two-dose vaccine recipients to neutralize SARS-CoV-2 strains B.1 (Wuhan/D614G), B.
View Article and Find Full Text PDFImplication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19.
Int J Immunopathol Pharmacol
September 2024
Background: The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into pathogenesis and potential therapeutic targets.
Objective: This study aimed to investigate the potential correlation between single nucleotide polymorphisms (SNPs) in , , , and genes and the severity as well as susceptibility to COVID-19 among Moroccan patients.
In the development of antiviral drugs, proteases and polymerases are among the most important targets. Cysteine proteases, also known as thiol proteases, catalyze the degradation of proteins by cleaving peptide bonds using the nucleophilic thiol group of cysteine. As part of our research, we are examining how cysteine, an essential amino acid found in the active site of the main protease (M) enzyme in SARS-CoV-2, interacts with electrophilic groups present in ethacrynic acid (EA) and compounds 4, 6, and 8 to form sulfur-carbon bonds.
View Article and Find Full Text PDFArticle Synopsis
- - This study explored the genetic, chemical, and biological properties of ten traditional Moroccan seed varieties, identifying two unique molecular profiles through DNA analysis and discovering a new gene sequence related to THCA synthase.
- - Chemical analysis revealed a total of 37 compounds, including 13 non-volatile chemicals (like inactive cannabinoids and polyphenols) and 24 volatile compounds, with 7 of these being newly identified in seed extracts.
- - The research also assessed the seeds' biological activities, showcasing their antioxidant, antimicrobial, cytotoxic, and potential antiviral effects, suggesting these seeds could be valuable for future nutritional and health-related studies.
TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Int J Immunopathol Pharmacol
May 2024
Objectives: This study aimed to explore the potential correlation between specific single nucleotide polymorphisms (TYK2, IFITM3, IFNAR2, and OAS3 variants) and the severity of COVID-19 in Moroccan patients.
Methods: A genetic analysis was conducted on 109 patients with PCR-confirmed SARS-CoV-2 infection in Morocco. Among these patients, 46% were hospitalized in the intensive care unit, while 59% were not hospitalized.