Publications by authors named "N Ton"
Article Synopsis
- LINCMD1 has previously been linked to muscle differentiation by acting as a sponge for miRNAs, but its role in the development of leiomyoma (a type of tumor) was not clear.
- This study analyzed tissue samples from patients and found that LINCMD1 levels were lower in leiomyoma tissues compared to surrounding myometrium, while miR-135b levels were higher in leiomyoma.
- The findings suggest that LINCMD1 could be a potential target for therapies aimed at correcting abnormal signaling pathways involved in leiomyoma development.
The role of long non-coding RNAs in fibroid pathogenesis remains largely unexplored. In a previous study, we found elevated XIST (X-inactive specific transcript) levels in fibroids, which sponged miR-29c and miR-200c, leading to the overexpression of their target genes. This study aimed to assess the therapeutic potential of XIST downregulation in fibroid treatment.
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- * Researchers tested the NF-kB inhibitor Bay 11-7082 on fibroid xenografts in mice, leading to a notable 50% reduction in tumor weight and decreased expression of various genes associated with growth, inflammation, and extracellular matrix composition.
- * The study's findings suggest that inhibiting NF-kB may be a promising approach for fibroid treatment, as it effectively reduces the expression of key genes that regulate cell proliferation and the inflammatory response.
: Malaria continues to be a significant global health challenge. The efficacy of artemisinin-based combination therapies (ACTs) has declined in many parts of the Greater Mekong Subregion, including Vietnam, due to the spread of resistant malaria strains. This study was conducted to assess the efficacy of the Dihydroartemisinin (DHA)-Piperaquine (PPQ) regimen in treating uncomplicated malaria and to conduct molecular surveillance of antimalarial drug resistance in Binh Phuoc and Dak Nong provinces.
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- Austronesian is the second-largest language family globally, mainly found in Island Southeast Asia and Oceania, with limited understanding of its spread in Mainland Southeast Asia.
- This study analyzed genetic data from 369 individuals with mitogenomes and 170 individuals' Y-chromosomal SNPs from Vietnamese Austronesian and neighboring Austroasiatic groups to uncover population connections.
- Results showed some genetic consistency with matrilocality among certain VN-AN groups and closer genetic ties with VN-AA groups, indicating that the spread of AN speakers involved both cultural and demic diffusion.