Publications by authors named "N Tohse"

Article Synopsis
  • Long noncoding RNAs (lncRNAs) are important in cancer development, but their roles in oral squamous cell carcinoma (OSCC) are not fully understood; LINC02154 has been found to be linked to worse outcomes in patients.
  • Knocking down LINC02154 in OSCC cells leads to cell cycle arrest and death, and reduces tumor growth by downregulating the gene FOXM1, which regulates cell cycle progression.
  • LINC02154 also interacts with proteins that stabilize FOXM1 and affects mitochondrial function, suggesting it could be a potential target for cancer therapies by influencing both cell cycling and energy production in OSCC cells.
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Background: Exercise, especially high-intensity interval training (HIIT), can increase mitochondrial respiratory capacity and enhance muscular endurance, but its systemic burden makes it difficult to safely and continuously prescribe for patients with chronic kidney disease (CKD)-related cachexia who are in poor general condition. In this study, we examined whether HIIT using electrical stimulation (ES), which does not require whole-body exercise, improves muscle endurance in the skeletal muscle of 5/6 nephrectomized rats, a widely used animal model for CKD-related cachexia.

Methods: Male Wistar rats (10 weeks old) were randomly assigned to a group of sham-operated (Sham) rats and a group of 5/6 nephrectomy (Nx) rats.

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Article Synopsis
  • Humoral immunity is crucial for protecting the body, but faulty antibody responses can lead to inflammation and immune disorders.
  • T follicular helper (Tfh) cells are key players in this immune response, and the study focuses on the role of B-cell Oct-binding protein 1 (Bob1) in regulating these cells.
  • The research indicates that Bob1 is essential for maintaining Tfh cell function, especially in producing antibodies during immune responses, and that it significantly influences antibody production, including IgE, in asthma models triggered by allergens like house dust mites.
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Although platelet-rich plasma (PRP) has been widely used regardless of the severity of muscle strain, there have been very few basic studies in which its effects on muscle injury were examined by using models that accurately mimic the clinical muscle strain injury process. Therefore, the aim of this study was to confirm by physiological and structural analyses whether PRP purified by a general preparation method has a muscle healing effect on muscle damage caused by eccentric contraction (ECC). Male Wistar rats were subjected to muscle injury induced by ECC in bilateral plantar flexor muscles using electrical stimulation and an automatically dorsiflexing footplate.

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Chronic kidney disease (CKD)-related cachexia increases the risks of reduced physical activity and mortality. However, the physiological phenotype of skeletal muscle fatigue and changes in intramuscular metabolites during muscle fatigue in CKD-related cachexia remain unclear. In the present study, we performed detailed muscle physiological evaluation, analysis of mitochondrial function, and comprehensive analysis of metabolic changes before and after muscle fatigue in a 5/6 nephrectomized rat model of CKD.

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