Indicators of dementia disease progression in primary care: An electronic health record cohort study.

Background And Purpose: The objectives were to assess the feasibility and validity of using markers of dementia-related health as indicators of dementia progression in primary care, by assessing the frequency with which they are recorded and by testing the hypothesis that they are associated with recognised outcomes of dementia. The markers, in 13 domains, were derived previously through literature review, expert consensus, and analysis of regional primary care records.

Methods: The study population consisted of patients with a recorded dementia diagnosis in the Clinical Practice Research Datalink, a UK primary care database linked to secondary care records.

Markers of dementia-related health in primary care electronic health records.

Objectives: Identifying routinely recorded markers of poor health in patients with dementia may help treatment decisions and evaluation of earlier outcomes in research. Our objective was to determine whether a set of credible markers of dementia-related health could be identified from primary care electronic health records (EHR).

Methods: The study consisted of (i) rapid review of potential measures of dementia-related health used in EHR studies; (ii) consensus exercise to assess feasibility of identifying these markers in UK primary care EHR; (iii) development of UK EHR code lists for markers; (iv) analysis of a regional primary care EHR database to determine further potential markers; (v) consensus exercise to finalise markers and pool into higher domains; (vi) determination of 12-month prevalence of domains in EHR of 2328 patients with dementia compared to matched patients without dementia.

Reported wearing compliance of ready-made spectacles at 6 and 12 months.

Purpose: Ready-made spectacles are often used in low-resource environments, but to date, there has been little evaluation of the continued use of these spectacles over time. The aim of this study was to assess wearing compliance of those who received ready-made spectacles.

Methods: The International Rescue Committee trains refugee health workers to provide simple refractive services and dispense ready-made spherical lenses to residents of refugee camps on the Thailand-Burma border.

Pharmacological coal tar induces G:C to T:A transversion mutations in the skin of muta mouse.

Coal tar is a by-product of the distillation of coal. It consists of a complex chemical mixture of aromatic and aliphatic hydrocabons, with high concentrations of polycyclic aromatic hydrocarbons such as benzo[a]pyrene. We have previously shown that single painting on skin of mice increases the mutation frequency 16 times in murine epidermis cells (Thein et al.