Publications by authors named "N Tedla"
Article Synopsis
- Dengue is a significant health issue in low- and middle-income countries, with risks of severe outcomes like plasma leakage, making early patient identification crucial for effective hospital care.
- This study used a case-control approach to analyze plasma samples from dengue patients to identify potential biomarkers linked to plasma leakage within the first 96 hours of illness.
- Key findings showed that elevated levels of specific biomarkers (like Vascular cell adhesion molecule-1 and Interleukin 33 receptor) increased the risk of plasma leakage, while others (like eotaxin-1) were protective, highlighting their potential role in improving dengue patient care.
Article Synopsis
- Anti-GD2 antibody therapy offers benefits for neuroblastoma patients, but its effectiveness is limited by the tumor's immunosuppressive environment.
- Research shows that using copper chelation can enhance this therapy by improving immune responses, specifically by boosting the activity of neutrophils that help fight the tumor.
- The study suggests repurposing the approved copper chelator Cuprior as a safe and effective method to improve the outcomes of anti-GD2 therapy in neuroblastoma patients.
Background: Current literature informs us that bivalent vaccines will generate a broader serum neutralizing antibody response to multiple SARS-CoV-2 variants, but studies on how this breadth relates to the memory B cell (MBC) and T cell responses are sparse. This study compared breadth of neutralising antibody, and memory B and T cell responses to monovalent or a bivalent ancestral/Omicron BA.1 COVID-19 booster vaccine.
View Article and Find Full Text PDFPurpose: Limbal stem cell deficiency (LSCD) secondary to ocular surface alkali burn is a blinding condition that features corneal conjunctivalization. Mechanistic insights into its pathophysiology are lacking. Here, we developed a mouse model that recapitulates human disease to comprehensively delineate the clinicopathological features of a conjunctivalized cornea.
View Article and Find Full Text PDFBackground: Hepatitis C virus (HCV) is a significant concern within prison populations. Provision of HCV testing and treatment for people in prison is expanding and a key component of global elimination efforts. Despite growing service availability, several challenges remain in HCV testing and treatment engagement during incarceration.
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