Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells.

Background/objectives: Circadian clocks are endogenous systems that regulate numerous biological, physiological, and behavioral events in living organisms. Aging attenuates the precision and robustness of circadian clocks, leading to prolonged and dampened circadian gene oscillation rhythms and amplitudes. This study investigated the effects of food-derived polyphenols such as ellagic acid and its metabolites (urolithin A, B, and C) on the aging clock at the cellular level using senescent human fibroblast cells, TIG-3 cells.

[Prophylactic Negative Pressure Wound Therapy for Patients at High Risk of Surgical Site Infection in Cardiovascular Surgery].

Background: Deep sternal wound infection after cardiovascular surgery is one of the most devasting complications in both a short and long term. The addition of prophylactic negative pressure wound therapy( pNPWT) to standard surgical site infection( SSI) prophylaxis could be promising approach for the reduction of this problem.

Methods: We evaluated 117 consecutive patients who underwent median sternotomy for cardiovascular surgery at our institution from July 2021 to December 2021.

Horner's syndrome caused by the first rib fracture sustained during coronary artery bypass grafting: a case report and literature review.

Background: Horner's syndrome is a rare complication of cardiovascular surgery. A bone fragment and hematoma due to rib fracture after cardiac surgery may cause injury to the brachial nerve plexus and sympathetic nerve trunk, leading to neurologic disorders and Horner's syndrome. However, few reports have revealed the etiology of Horner's syndrome after cardiovascular surgery based on imaging.

Pseudoaneurysm formation after embolization of giant arteriovenous malformation of the lower limb associated with Parkes Weber syndrome: A case report and literature review.

A 63-year-old woman presented with a giant arteriovenous malformation (AVM) of the lower limbs associated with Parkes Weber syndrome (PWS). The AVM was supplied by 4 branches of the right profunda femoris artery and 4-stage embolization was performed. At 67 years of age, she developed a pseudoaneurysm due to the recanalization of a coiled profunda femoris artery branch arterial aneurysm.