Effectiveness of Chemoimmunotherapy in Small-cell Lung Cancer Patients With a Poor Performance Status or Higher Neutrophil/Lymphocyte Ratio.

Background/aim: Chemoimmunotherapy has improved overall survival in patients with extensive small-cell lung cancer (SCLC). However, the backgrounds of patients enrolled in clinical trials tend to differ from those of patients treated in clinical practice, and the effectiveness of chemoimmunotherapy may be unclear in some populations, including patients with poor performance status. This study aimed to evaluate the effectiveness of chemoimmunotherapy for SCLC patients in clinical practice while focusing on several subgroups.

Effect of Oral Nutritional Supplements Composed of High Protein on Body Weight Loss After Gastrectomy.

Background/aim: Body weight loss (BWL) after gastrectomy for gastric cancer (GC) decreases postoperative quality of life and survival in patients with GC. This study aimed to evaluate the effect of oral nutritional supplements composed of high protein on BWL in the early period following gastrectomy.

Patients And Methods: Pre- and postoperative body weight and skeletal muscle mass were measured using bioelectrical impedance analysis in patients undergoing radical gastrectomy for GC and analyzed retrospectively.

Crystal structures of two different multi-component crystals consisting of 1-(3,4-di-meth-oxy-benz-yl)-6,7-di-meth-oxy-iso-quinoline and fumaric acid.

Two different multi-component crystals consisting of papaverine [1-(3,4-di-meth-oxy-benz-yl)-6,7-di-meth-oxy-iso-quinoline, CHNO] and fumaric acid [CHO] were obtained. Single-crystal X-ray structure analysis revealed that one, CHNO·1.5CHO (I), is a salt co-crystal composed of salt-forming and non-salt-forming mol-ecules, and the other, CHNO·0.

Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice.

Aim: Although several therapeutic agents show efficacy in advanced hepatocellular carcinoma (HCC), biomarkers such as comprehensive genomic profiling (CGP) for the selection of second-line treatments after immunotherapy have not been established. We evaluated the value of CGP for the treatment decision in patients with HCC.

Methods: We retrospectively studied 52 patients with advanced HCC who received CGP tests at three tertiary hospitals between February 2022 and November 2023.

Enhancing Capillary Pressure of Porous Aluminum Wicks by Controlling Bi-Porous Structure Using Different-Sized NaCl Space Holders.

Capillary pressure and permeability of porous media are important for heat transfer devices, including loop heat pipes. In general, smaller pore sizes enhance capillary pressure but decrease permeability. Introducing a bi-porous structure is promising for solving this trade-off relation.