Publications by authors named "N Takasu"
Article Synopsis
- Scientists found that using a special protein called H1FOO-DD helps improve how well human cells can be turned into pluripotent stem cells, which can become any type of cell in the body.
- This method makes sure the new stem cells are more similar to each other and better at becoming different types of cells when needed.
- The research shows that a certain protein, FKBP1A, is important for this process to work effectively.
Article Synopsis
- Many female mammals, including rodents, have cyclical reproductive behaviors that are influenced by reproductive hormones and circadian rhythms.
- Disruption in these circadian rhythms can negatively affect estrous cycles, leading to fewer pregnancies in mice.
- Extending the length of daylight by just 2 hours can normalize estrous cycles in mice, suggesting that increasing light exposure may enhance reproductive success.
Naive human induced pluripotent stem cells (iPSCs) can be generated by reprogramming somatic cells with Sendai virus (SeV) vectors. However, only dermal fibroblasts have been successfully reprogrammed this way, and the process requires culture on feeder cells. Moreover, SeV vectors are highly persistent and inhibit subsequent differentiation of iPSCs.
View Article and Find Full Text PDFBackground: Human induced pluripotent stem cells (iPSCs) are expected to be useful for regenerative medicine for many diseases. Many researchers have focused on and enabled the generation of differentiated cells or tissue-like structures, including organoids, which help to ameliorate target diseases. To promote such cell therapies, we established a clinically applicable iPSC haplobank matching as many people as possible in Japan.
View Article and Find Full Text PDFA 51-year-old female patient visited our department with a complaint of pain in the left breast. She was found to have Stage Ⅳ breast cancer with liver metastasis. The biopsy-based historical diagnosis was triple negative breast cancer(TNBC).
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