Publications by authors named "N T Ventham"
Article Synopsis
- * Using data from over 450,000 individuals in the UK Biobank, the researchers found that higher exposure to specific air pollutants, like NO and PM, was significantly associated with the development of UC, but not CD.
- * The research suggests that air pollution may cause UC through epigenetic changes, particularly in genes such as CXCR2 and areas related to the immune system, with lifestyle and genetic factors playing a role in this relationship.
Background: Emergency colorectal surgery carries a high risk of morbidity and mortality. Subspecialisation and split-site geographically distinct services may lead to critically unwell patients presenting to a non-colorectal specialist centre requiring urgent on-site intervention.
Aims: This study aims to determine outcomes of this high-risk patient cohort.
The genetic contribution to inflammatory bowel disease (IBD) encompassing both Crohn's disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterise environmental and epigenetic influences. Recently considerable progress has been made in characterising the adult methylome, in epigenome-wide association studies. We report detailed analysis of the circulating methylome in 86 patients with childhood-onset CD,UC and 30 controls using the Illumina Infinium Human MethylationEPIC platform.
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- - This study explores the link between smoking and the risk of developing inflammatory bowel disease (IBD), specifically focusing on Crohn's disease (CD) and ulcerative colitis (UC) through cohort and Mendelian randomization studies.
- - Findings show that current and past smoking habits significantly increase the risk of CD and UC, with specific DNA methylation changes (e.g., at genes like DNMT3A and AHRR) linked to these risks.
- - The research identifies biological mechanisms underlying how smoking contributes to the development of IBD, providing insights into the pathways involved in this condition.
Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA methylome in patients requiring surgery may predict Crohn's disease (CD) recurrence following intestinal resection; and second to compare the circulating methylome seen in patients with established CD with that we had reported in a series of inception cohorts.
Methods: TOPPIC was a placebo-controlled, randomized controlled trial of 6-mercaptopurine at 29 UK centers in patients with CD undergoing ileocolic resection between 2008 and 2012.