Publications by authors named "N T Sindhu"
Membrane protein shedding is a key regulatory mechanism for cell signaling and adhesion, and dysregulated shedding is associated with diseases. Many membrane proteases can catalyze shedding, but the substrate spectra and downstream targets of these "sheddases" remain largely elusive. While secretomics-based methods have been applied to the systematic identification of sheddase substrates, these methods are not always effective and do not provide much information on downstream targets.
View Article and Find Full Text PDFBackground: The World Health Organization (WHO) declared Coronavirus disease-19 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a pandemic on March 11, 2020. On 16 January 2021, India began its vaccination programme using two COVID-19 vaccines (Covishield and Covaxin). Precautionary dose (booster shots) was administered to health and front-line workers in the beginning and then to all eligible populations.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on examining the safety of the Covaxin vaccine in adolescents aged 15-18 in a district of Northern India, assessing any adverse events following immunization (AEFI).
- - Conducted over one year (January to December 2022) at various rural and urban health centers, the study included 72,771 adolescents for the first dose and 49,046 for the second dose of Covaxin, monitoring any potential side effects.
- - Results showed no reported adverse drug events, leading to the conclusion that Covaxin is safe for use in adolescents within this age group.
Purpose: The Maternal Antecedents of Adiposity and Studying the transgenerational role of Hyperglycaemia and Insulin cohort in Bengaluru, South India, aims to understand the transgenerational role of increased circulating glucose levels or hyperglycaemia and other nutrients and psychosocial environment, on the risk of childhood obesity, as an early marker of chronic diseases.
Participants: Through this paper, we describe the baseline characteristics of the cohort participants and their children, along with plans and challenges. A total of 5694 pregnant women were screened, with 4862 (85.