Cervical Lymph Node Metastasis of Unknown Origin and Remote Primary at a Tertiary Cancer Centre in North India: Case Series with Review of Literature.

Carcinoma of unknown primary site represents a heterogeneous group of malignancies that present with lymph node or distant metastases, for which diagnostic work-up fails to identify the site of origin. Their incidence relative to total head and neck cancers ranges from as low as 1.7 to 2.

Initial Functional and Anatomical Outcomes of High-Dose Aflibercept 8 mg in Exudative Neovascular Age-Related Macular Degeneration.

Purpose: To evaluate the short-term outcomes of patients with exudative neovascular age-related macular degeneration (nAMD) treated with high-dose aflibercept 8.0 mg (HDA), focusing on anatomical and functional changes, as well as the feasibility of extending treatment intervals in real-world clinical practice.

Design: Retrospective, noncomparative cohort study.

Transcriptional dynamics of porcine granulosa cells during cellular acclimation to thermal challenge.

Investigations on heat stress induced transcriptomic changes is critical to characterization of candidate genes for thermal adaptability in livestock. Continues spells of high ambient temperature due to climate change has amplified reproductive dysfunctions, necessitating immediate attention. The present study aimed to explore the transcriptomic signature of heat stressed granulosa cells (GCs) and signalling pathways regulating their adaptability to thermal challenge.

Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.

Oncogenic protein dosage is tightly regulated to enable cancer formation but how this is regulated by translational control remains unknown. The Myc oncogene is a paradigm of an exquisitely regulated oncogene and a driver of pancreatic ductal adenocarcinoma (PDAC). Here we use a CRISPR interference screen in PDAC cells to identify activators of selective MYC translation.