Publications by authors named "N T Kalyana Sundaram"
Article Synopsis
- Percutaneous image-guided needle biopsies are a safe and minimally invasive procedure used to obtain tissue from bone lesions, with radiologists playing a crucial role in patient care and coordination with clinical teams for accurate diagnoses.
- The review emphasizes the importance of patient selection, imaging workup, and managing risks like bleeding and thrombosis before conducting biopsies, often performed under moderate sedation for patient comfort.
- While computed tomography is the primary method for guidance, advancements in powered drill technology are improving the safety and efficiency of sampling from tough bone lesions, along with discussions on special techniques for challenging anatomical regions.
Public engagement to refine a whole-school intervention to promote adolescent mental health.
Public Health Res (Southampt)
December 2024
Background: Despite high rates of adolescent mental health problems, there are few effective school-based interventions to address this. Whole-school interventions offer a feasible and sustainable means of promoting mental health, but few have to date been evaluated. Previously we trialled the Learning Together intervention comprising local needs assessment, student and staff participation in decision-making, restorative practice, and a social and emotional skills curriculum.
View Article and Find Full Text PDFBackground: Despite high rates of adolescent mental-health problems, there are few effective whole-school interventions to address this. Whole-school interventions offer a feasible and sustainable means of promoting mental health. We previously evaluated the Learning Together (LT) intervention which was effective in preventing bullying (primary outcome), promoting mental well-being, psychological functioning, and reducing substance use (secondary outcomes).
View Article and Find Full Text PDFThe kidney maintains homeostasis through an array of parallel nephrons, which all originate in development as isolated epithelial structures that later fuse through their distal poles to a system of collecting ducts (CD). This connection is required to generate functional nephrons by providing a pathway for excretion of metabolic waste and byproducts. Currently, methods for differentiating human pluripotent stem cells into kidney organoids generate nephrons that lack CDs and instead terminate as blind-ended tubules.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on tissue engineering aimed at repairing the small bowel using human intestinal organoids (HIOs) created from human pluripotent stem cells.
- Researchers tested the ability of these organoids to engraft and aid healing in a rodent model with acute bowel damage, showing they can proliferate and integrate into various layers of the intestine.
- Key results included the restoration of the mucosal layer, integration into muscle and blood vessel tissues, and the long-term presence of diverse cell types, highlighting the role of mesenchyme in effective intestinal repair.