Laryngeal inflammatory myofibroblastic tumor.

Inflammatory myofibroblastic tumor seldom involves the larynx, as only about 50 to 60 cases have been described in the literature. Even though these tumors are often not aggressive, they have the potential for invasion and local recurrence. We describe the case of a 27-year-old man who was admitted to an emergency department with signs of upper airway obstruction secondary to an obstructive mass.

Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas.

Mutations in the p53 tumor suppressor gene are present in approximately 50% of all human cancers. We sought to determine the frequency and type of p53 mutations in squamous cell carcinomas (SCC) of the oral cavity in a Brazilian population. To identify p53 mutations we used PCR-SSCP in tumor tissue microdissected from paraffin- embedded and from fresh-frozen sections followed by direct sequencing of SSCP bands with altered electrophoretic mobility.

Ganglioneuroma of the neck, masquerading as a goiter.

We report a case of patient with a suspected goiter which proved ganglioneuroma adjacent to the thyroid gland. Preoperative studies were not diagnostic. Ganglioneuroma should be kept in mind during the differential diagnosis of goiter.