Publications by authors named "N T Han"
The cost-effectiveness of whole exome sequencing (WES) remains controversial due to variant call variability, necessitating sensitivity and specificity evaluation. WES was performed by three companies (AA, BB, and CC) using reference standards composed of DNA from hydatidiform mole and individual blood at various ratios. Sensitivity was assessed by the detection rate of null-homozygote (N-H) alleles at expected variant allelic fractions, while false positive (FP) errors were counted for unexpected alleles.
View Article and Find Full Text PDFBackground: The stress hyperglycemia ratio (SHR) has recently gained attention as a marker for acute hyperglycemia, which has been linked to adverse clinical outcomes. However, its independent role in the development of type 2 diabetes (T2D) remains understudied. This cohort study aimed to assess the association between SHR and the incidence of T2D.
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- The study examined how the antioxidant capacities of Korean red pine bark are affected by digestion, finding significant changes in phenolic compounds during the process.
- Gastric digestion increased key compounds like procyanidin B1 and catechin, but most were degraded in the intestines, highlighting a focus on protocatechuic acid.
- The results suggest taxifolin as a key phenolic compound contributing to antioxidant effects, indicating potential for RPB as a natural antioxidant in dietary supplements.
Article Synopsis
- - The study examined how glass transition and stickiness impacted the spray drying of fermented reconstituted skim milk (RSM), finding that the process resulted in issues with wall deposits without the addition of skim milk powder (SMP).
- - When SMP was added, the drying process improved significantly, with heightened temperatures for the glass transition and sticky point, helping the droplets transform from a sticky state to a non-sticky glassy state during drying.
- - Despite the spray-dried powder having higher moisture sorption and lactose crystallization, the relationship between glass transition effects suggests that its shelf stability at room temperature could be comparable to that of the control group.
Background: Brain metastases are a common complication in patients with non-small-cell lung cancer (NSCLC) lacking actionable driver mutations, with limited treatment options and poor prognosis. We aimed to investigate the efficacy and safety of brain radiotherapy combined with camrelizumab and platinum-doublet chemotherapy in patients with newly diagnosed advanced NSCLC and brain metastases.
Methods: This multicentre, single-arm, phase 2 trial was done across nine tertiary hospitals in China.