Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.

Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to analyse subtypes of tyrosine hydroxylase (TH)-positive dopaminergic midbrain neurons in mouse and human brain-sections. These neurons modulate complex behaviour, and are differentially affected in Parkinson's and other diseases.

β2-subunit alternative splicing stabilizes Cav2.3 Ca channel activity during continuous midbrain dopamine neuron-like activity.

In dopaminergic (DA) (SN) neurons Cav2.3 R-type Ca-currents contribute to somatodendritic Ca-oscillations. This activity may contribute to the selective degeneration of these neurons in Parkinson's disease (PD) since Cav2.

Health concepts of elementary school pupils in Austria : An explorative study using the draw and write technique.

Studies analysing health concepts of children are scarce. Thus, the aim of this study was to analyse health concepts of elementary school children in Austria. In all, 240 pupils in grades 2 (7 or 8 years old) and 4 (9 or 10 years old) of three rural and three urban elementary schools in Styria took part in this explorative study.

Pronounced social inequality in health-related factors and quality of life in women and men from Austria who are overweight or obese.

Background: The burden of social inequalities in health as well as the association between obesity with morbidity and mortality is a worldwide problem. Therefore, the aim of our study was to investigate health-related factors, health, and quality of life in Austrian women and men with normal weight, overweight, and obesity with a different socioeconomic status (SES) based on actual data from 2015.

Methods: This representative population-based study was based on self-reported data of 15,338 Austrian adults (8,425 women and 6,933 men) in 2014/2015.

Body image disturbances, fear and associations with the amygdala in anorexia nervosa.

Background: Anorexia nervosa (AN) is a severe illness with a high mortality rate which mainly affects young women. Studies found a localized volume loss of the amygdala in patients with AN, a brain region responsible for affective responses. Patients with AN were found to have body image distortions, and suffer from the comorbid disorders depression, anxiety disorder, and obsession.