Multicentennial cycles in continental demography synchronous with solar activity and climate stability.

Human population dynamics and their drivers are not well understood, especially over the long term and on large scales. Here, we estimate demographic growth trajectories from 9 to 3 ka BP across the entire globe by employing summed probability distributions of radiocarbon dates. Our reconstruction reveals multicentennial growth cycles on all six inhabited continents, which exhibited matching dominant frequencies and phase relations.

The multidrug resistance protein 4 is expressed and functionally active in isolated bladder from pig.

Multidrug resistance proteins type 4 (MRP4) and 5 (MRP5) play pivotal roles in the transport of cyclic nucleotides in various tissues. However, their specific functions within the lower urinary tract remain relatively unexplored. This study aimed to investigate the effect of pharmacological inhibition of MRPs on cyclic nucleotide signaling in isolated pig bladder.

Metabolic Stability and Metabolite Identification of N-Ethyl Pentedrone Using Rat, Mouse and Human Liver Microsomes.

New Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications of traditional drugs. These molecules represent a public health problem since information about their metabolites and toxicity is poorly understood. N-ethyl pentedrone (NEP) is an NPS that was identified in the illicit market for the first time in the mid-2010s, with four intoxication cases later described in the literature.