Publications by authors named "N Sutandyo"
Background And Aim: Non-small cell lung cancer (NSCLC) is the most common lung cancer found in elderly patients. Aging and chronic inflammation are related to its pathogenesis. Functional status, lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio describe a chronic inflammation and correlate to the survival of older adults with advanced-stage (IIIB-IV) NSCLC.
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- Cytogenetics plays a critical role in diagnosing and predicting outcomes for myelodysplastic syndrome (MDS), with specific profiles indicating a higher risk of progression to acute myeloid leukemia (AML).
- This study focused on Indonesian patients with MDS, assessing their cytogenetic profiles through clinical examinations and follow-ups over one year.
- Key findings included the identification of monosomy 7 and chromosome 5 deletions in certain patients, along with a notable risk of AML transformation in those with MDS-EB.
Article Synopsis
- Breast cancer is a significant health issue in Indonesia, prompting a study to explore potential biomarkers, specifically mitochondrial DNA copy number (mtDNA-CN) and relative telomere length (RTL), which are linked to oxidative stress.
- Researchers conducted a case-control study comparing blood samples from 175 breast cancer patients to 181 healthy individuals, utilizing quantitative real-time PCR for analysis.
- Results showed that younger breast cancer patients (under 48) had higher mtDNA-CN and RTL compared to healthy individuals, indicating these biomarkers might be useful for early breast cancer risk assessment.
Objective: This study aimed to investigate the associations of CD8+, PARP, and EGFR expressions with two-year survival in patients with triple-negative breast cancer (TNBC).
Methods: A retrospective cohort study was conducted in a national cancer center. All patients aged 18 years diagnosed with TNBC (2013-2017) were included and followed for 24 months or until the patients were deceased.
The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.
BMC Res Notes
February 2024
Background: Triple-negative breast cancer (TNBC) has been documented as the most aggressive subtype of breast cancer. This study aimed to analyze antitumor and protumor immune activities, and their ratios as significant prognostic biomarkers in metastatic TNBC (mTNBC).
Methods: A multicenter cohort study was conducted among 103 de novo mTNBC patients.