Publications by authors named "N Sussman"
Article Synopsis
- Acetaminophen (APAP) and ischemic hepatic injury (IH) often show similar biochemical patterns, making it tough to distinguish between them in acute liver failure cases.
- A study analyzed over 3,300 patients to identify why diagnosing these conditions is difficult and to test a new APAP-CYS adduct assay for better accuracy.
- The findings indicated that the APAP-CYS test led to diagnosis revisions in about 14.6% of cases, with a small number showing evidence of both APAP and IH injuries combined.
Most patients with alcohol-associated liver disease (ALD) engage in heavy drinking defined as 4 or more drinks per day (56 g) or 8 (112 g) or more drinks per week for women and 5 or more drinks per day (70 g) or 15 (210 g) or more drinks per week for men. Although abstinence from alcohol after diagnosis of ALD improves life expectancy and reduces the risk of decompensation of liver disease, few studies have evaluated whether treatment of alcohol use disorders will reduce progression of liver disease and improve liver-related outcomes. In November 2021, the National Institute of Alcohol Abuse and Alcoholism commissioned a task force that included hepatologists, addiction medicine specialists, statisticians, clinical trialists and members of regulatory agencies to develop recommendations for the design and conduct of clinical trials to evaluate the effect of alcohol use, particularly treatment to reduce or eliminate alcohol use in patients with ALD.
View Article and Find Full Text PDFStudy in Patients With Unilateral Horner Syndrome Supports the Role of Müller's Muscle in the Eyelid-Dark Reflex.
Invest Ophthalmol Vis Sci
November 2023
Article Synopsis
- A study was conducted to investigate how Müller's muscle affects eyelid movement when lighting conditions change from bright (photopic) to dark (scotopic).
- The research involved patients with unilateral Horner syndrome, comparing their affected eyes (with sympathetic nerve damage) to the unaffected eyes using advanced imaging techniques.
- Results showed that eyelid retraction in response to dim light was significantly less in the affected eyes, suggesting that Müller's muscle plays a crucial role in this reflex.
Background: The etiology of acute liver failure (ALF) remains one of the most important factors in determining prognosis and predicting outcomes. In a significant proportion of ALF cases, however, the etiology remains unknown and is categorized as indeterminate ALF (IND-ALF). In this study, we summarize findings from patients with IND-ALF from 32 transplant centers across the United States, and we compare laboratory, prognostic, and outcome data for patients with IND-ALF.
View Article and Find Full Text PDFAutoimmune hepatitis is a common cause of acute liver failure. Treatment includes steroids for acute liver injury and liver transplantation in those who fail to respond or develop acute liver failure. The aim of this study is to further characterize acute liver failure secondary to autoimmune hepatitis and identify variables that predict 21-day transplant-free survival.
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