Publications by authors named "N Sugita"

Femtosecond laser-induced plasma filaments have potential for various applications including attosecond physics, spectroscopy, and microprocessing. However, the use of plasma filaments to generate high-aspect-ratio internal modifications remains low-efficiency. Here, we experimentally demonstrated high-efficiency internal processing using plasma filaments induced by a double-pulse femtosecond laser.

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Background: Post-stroke delirium affects between 24% and 43% of patients, and negatively impacts patient outcomes. Recently, research attention has been on preventive interventions for delirium, with melatonin receptor agonists and orexin receptor antagonists reported to be effective in preventing delirium in intensive care unit patients. However, the efficacy of these agents in preventing post-stroke delirium remain unclear.

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Background: Although central disorders of hypersomnolence (CDH) and attention-deficit/hyperactivity disorder (ADHD) are frequently comorbid, they often remain underdiagnosed, leading to insufficient treatment and sociopsychological outcomes.

Case Presentation: Here, we present a case of a male in his late 20s with ADHD and autism spectrum disorder who exhibited symptoms suggestive of idiopathic hypersomnia (IH), a subtype of CDH. The patient experienced difficulty waking up and dropped out of university.

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Article Synopsis
  • Megalin is a multi-ligand endocytic receptor found in the apical membrane of proximal tubules and is noted for its presence in human urine in both ectodomain and full-length forms, with ectodomain being more prevalent.
  • The study developed and validated two types of sandwich ELISAs—A-megalin and C-megalin—to specifically measure the ectodomain and full-length forms of megalin, respectively, in mouse urine.
  • Findings indicated that A-megalin and C-megalin were detectable in normal mouse urine, but significantly reduced in mice with a megalin-knockout, highlighting the predominance of ectodomain forms in urine.
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Low-frequency sonophoresis has emerged as a promising minimally invasive transdermal drug delivery method. However, effectively inducing cavitation on the skin surface with a compact, low-frequency ultrasound transducer poses a significant challenge. This paper presents a modified design of a low-frequency ultrasound transducer capable of generating ultrasound cavitation on the skin surfaces.

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