Coil embolization of vertebro-vertebral arteriovenous fistula: a case report.

Background: Vertebro-vertebral arteriovenous fistulas (VVFs) are not uncommon, but they usually present with benign symptoms such as neck murmur. We report a case of VVF presenting with myelopathy which was successfully treated by embolization with detachable coils.

Case Presentation: A 72-year-old woman was admitted with complaint of bilateral leg weakness.

Evaluation of intra-aneurysmal blood flow by digital subtraction angiography: blood flow change after coil embolization.

Background: The natural course of cerebral aneurysms is related to many factors, and it is very important that intra-aneurysmal blood flow is considered. Our group developed a method that allowed the simultaneous evaluation of blood flow in human cerebral aneurysms using digital subtraction angiography (DSA) with no special devices. The intra-aneurysmal blood flow measurement would also be very useful for coil embolization.

[A chronic intracerebral hematoma for which corticosteroid was effective: case report].

Chronic intracerebral hematoma is rare. Computerized tomography almost consistently demonstrates ring-shaped lesions with mass effect and perifocal edema. All patients in published studies have been treated surgically.

Function of aberrant EGFR in malignant gliomas.

The most common alteration of the epidermal growth factor receptor (EGFR) gene in human malignant gliomas is an in-frame deletion of exon 2-7 from the extra-cellular domain. To study the relationship between the expression of this aberrant EGFR and cell proliferation, as well as apoptosis in malignant gliomas, we have developed U-87MG cell transfectants that express the aberrant (mutant-type) or normal (wild-type) EGFR. We analyzed cell number, tumor volume, and MIB-1 positive rate as proliferation markers, and found that in tissue culture, tumors derived from U-87 MG cells (mutant-type) have the same proliferative activity as those derived from U-87 MG cells (wild-type).

An antisense EGFR oligodeoxynucleotide enveloped in Lipofectin induces growth inhibition in human malignant gliomas in vitro.

Epidermal growth factor receptor (EGFR) plays an important role in the progression of malignancy in gliomas. We studied the growth inhibition of the malignant glioma cell lines using an antisense EGFR oligodeoxynucleotide enveloped with Lipofectin. At a concentration of 5 microM of the antisense EGFR oligodeoxynucleotide enveloped with Lipofectin, the proliferation of three malignant glioma cell lines was significantly inhibited (p < 0.