Publications by authors named "N Suffee"
Recent epidemiological studies have shown that patients with right-sided breast cancer (RBC) treated with X-ray irradiation (IR) are more susceptible to developing cardiovascular diseases, such as arrhythmias, atrial fibrillation, and conduction disturbances after radiotherapy (RT). Our aim was to investigate the mechanisms induced by low to moderate doses of IR and to evaluate changes in the cardiac sympathetic nervous system (CSNS), atrial remodeling, and calcium homeostasis involved in cardiac rhythm. To mimic the RT of the RBC, female C57Bl/6J mice were exposed to X-ray doses ranging from 0.
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- * Early intermittent feeding of mice on a high-cholesterol diet speeds up atherosclerosis by altering arterial macrophage behavior and gene expression associated with ASCVD.
- * The Young Finns Study links early cholesterol exposure to increased carotid atherosclerotic plaque in adulthood, emphasizing the need for better hyperlipidaemia management early in life to prevent ASCVD.
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- * A high-fat diet (HFD) changes how Trp is processed in the body and can lead to inflammation, which might worsen heart problems.
- * This study shows that controlling Tryptophan metabolism could help reduce gut inflammation and heart disease, leading to new treatment options.
Article Synopsis
- A high-fat diet (HFD) alters gut microbiota, which drives the progression of atherosclerosis, while a high-cholesterol diet does not have the same effect.
- Low fiber intake further exacerbates this microbiota dysbiosis, leading to increased proliferation of gut immune cells that migrate to sites of atherosclerotic plaques.
- The research highlights a potentially important link between diet, gut microbiome changes, and immune responses in atherosclerosis, suggesting that modifying the gut microbiome could serve as a treatment strategy.