Publications by authors named "N Stokes"
Article Synopsis
- * A study demonstrates that metallothionein (MTH) immunohistochemistry (IHC) is a highly effective diagnostic method for WD, showing high sensitivity (91.20%) and perfect specificity (100%) in a cohort of 91 patients compared to control samples.
- * MTH IHC could serve as a cost-effective and reliable screening tool for diagnosing WD in patients of different ages and disease stages, enhancing patient evaluation and management.
The emergence of SARS-CoV-2 and seasonal outbreaks of other respiratory viruses highlight the urgent need for broad-spectrum antivirals to treat respiratory tract infections. Stimulator of interferon genes (STING) is a key component of innate immune signaling and plays a critical role in protection of the host against viral infections. Previously the STING agonist diABZI-4, a diamidobenzimidazole-based compound, demonstrated protection against SARS-CoV-2 both and .
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- * The oligosaccharyltransferase (OST) complex, particularly the STT3A/B enzymes, plays a crucial role in this glycosylation and has emerged as a promising target for broad-spectrum antiviral drugs.
- * The study highlights the balance between the antiviral potential of STT3A/B inhibitors, like NGI-1, and the need to assess their safety for humans, leading to the discovery of improved compounds that ensure both efficacy and lower toxicity risks.
Background: Containment (e.g. physical restraint and seclusion) is used frequently in mental health inpatient settings.
View Article and Find Full Text PDFNeutrophil extracellular traps (NETs) represent a recently discovered polymorphonuclear leukocyte-associated ancient defence mechanism, and they have also been identified as part of polytrauma patients' sterile inflammatory response. This systematic review aimed to determine the clinical significance of NETs in polytrauma, focusing on potential prognostic, diagnostic and therapeutic relevance. The methodology covered all major databases and all study types, but was restricted to polytraumatised humans.
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