The impact of mitochondrial dysfunction on the pathogenesis of atherosclerosis.

Objective: Aim: To determine the role of mitochondrial dysfunction in the pathogenesis of atherosclerosis based on the analysis of research data and statistics from the MEDLINE, Scopus and Web of Science Core Collection electronic databases for 2007-2023.

Patients And Methods: Materials and Methods: A comprehensive review of literature sources from the MEDLINE, Scopus and Web of Science Core Collection electronic databases was conducted to critically analyse the data and determine the role of mitochondrial dysfunction in the pathogenesis of atherosclerosis.

Conclusion: Conclusions: In this review, we have summarized the latest literature data on the association between mitochondrial dysfunction and the development of atherosclerosis.

MANAGEMENT OF RISKS OF ADVERSE DRUG REACTIONS ACCORDING TO ADR REPORT FORM DATA FROM LVIV REGION HEALTHCARE FACILITIES IN 2022.

The study aimed to analyse the adverse drug reactions report form data received by the State Expert Center of the Ministry of Health of Ukraine from healthcare professionals in the Lviv region in 2022. Regarding specific types of medicines, the ones with proven cause-and-effect relationships that caused the highest frequency of adverse drug reactions incidents were chemotherapeutic agents (35.5%), medicines affecting the cardiovascular system (20.

[CHARACTERISTICS OF THE PROTECTIVE EFFECTS OF QUERTZETIN AND ITS WATER-SOLUBLE FORM CORVITIN IN THE MODEL OF DICLOFENAC-INDUCED GASTROPATHY].

Today, worldwide, there is an intensive search and development of new approaches to increasing the efficiency and safety of classical NSAIDs. In view of the many-sided nature of the pathogenesis of NSAIDs-gastropathy, in our opinion, to optimize the pharmacological effects of NSAIDs, first of all, to increase their safety can be by combining them with drugs with polytropical pharmacological properties. The aim of research - The characterize degree of gastroprotective effect of quercetin (corvitin) in comparison with antisecretory drugs, misoprostol and De-Nol in diclofenac-induced gastropathy.

Study of biocompatibility of peritoneal dialysis solutions measured as in vitro cells viability.

This paper presents the comparable viability study results of the HepG2 and Vero cells in the presence of traditional peritoneal dialysis (PD) solutions determined by three methods (3-[4,5-dimethylthiazol]-2-yl-2,5-diphenyl tetrazolium bromide (MTT), neutral red (NR) and sulforhodamine B assays) with establishing different correlations between viability and quality indexes of the tested PD solutions. The obtained results confirmed cytotoxicity of the PD solutions even compared with an isotonic solution of sodium chloride. PD solutions action resulted in a similar reduction in the HepG2 and Vero cells.

[The characteristics of the analgesic action of nitrosorbide and no-shpa].

The study was conducted on experimental models of pain sense induced in mice by exposure to thermic or chemical factors and in rats by exposure to electric factors. Nitrosorbide and no-spa possess a dose-dependent analgesic effect. Both drugs excelled analgin in the intensity and duration of analgesic effect.