Reduced neorectal capacitance is a more important factor for impaired defecatory function after rectal resection than the anal sphincter pressure.

Objective: The role of the diverse anorectal diagnostic tools like manometry and determination of the preception threshold and the maximal tolerable volume is still a matter of debate. Currently, there is a scarcity of physiological data in the long-term follow-up of patients who underwent sphincter-preserving rectal resection. The aim of this study was therefore to perform these anorectal physiological measurements and to correlate the determined parameters with a faecal incontinence score.

Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum.

The purpose of this study was to investigate the differential involvement of distinct types of opioid receptors in the modulation of intestinal peristalsis compared to electrically induced longitudinal muscle contractions. Like naloxone, the proposed sigma-agonist and mu-antagonist SKF 10,047 (N-allyl-normetazocine) dose-dependently enhanced peristaltic circular muscle contractions in the isolated guinea-pig ileum. Pre-application of SKF 10,047 at a concentration which itself enhanced peristalsis by 20% on average strongly attenuated the inhibition of peristalsis produced by opioids previously proposed to act via mu-opioid-receptors in the guinea-pig ileum, i.

Opiate tolerance/dependence in the isolated guinea pig ileum is associated with an increased sensitivity to acetylcholine.

The number of rhythmic circular muscle contractions elicited by acetylcholine was increased in isolated intestinal segments taken from morphine-tolerant/dependent guinea pigs and exposed in vitro to an adequate normorphine concentration. Segments which underwent a partial withdrawal in vitro showed some degree of supersensitivity to acetylcholine which was, however, not significant. In contrast, basal peristaltic reflex activity was enhanced during a partial opiate withdrawal but not during exposure of the segments to a normorphine concentration high enough to maintain opiate tolerance/dependence.