Publications by authors named "N Srisurat"
Background: Melioidosis is an infectious disease caused by Burkholderia pseudomallei. Septicemic melioidosis patients have a high mortality rate within 48 hours.
Objective: To develop a polymerase chain reaction (PCR) combined with a lateral flow dipstick (LFD) assay for detection of B.
is a newly named species previously described as a divergent lineage of that has recently been shown to have a global distribution. Despite growing evidence of the clinical importance of this species, knowledge about its population epidemiology and genomic architecture is limited. We used whole-genome sequencing to evaluate and compare ( = 251) and ( = 68) isolates from adults with staphylococcal sepsis at several hospitals in northeastern Thailand between 2006 and 2013.
View Article and Find Full Text PDFTLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.
Clin Microbiol Infect
January 2017
Article Synopsis
- The study aims to understand how certain genetic pathways related to pathogen recognition receptors affect immune responses in Staphylococcus aureus sepsis.
- Researchers examined a specific genetic variant in the TLR4 gene and its association with cytokine responses to S. aureus in both laboratory settings and a cohort of Thai patients with sepsis.
- Findings suggest that a variant in TLR4 is linked to increased cytokine levels and respiratory failure in patients, indicating that immune responses to S. aureus share similarities with responses to Gram-negative bacteria, despite S. aureus not activating TLR4 directly.
Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013.
View Article and Find Full Text PDFComparative in vitro activity of sitafloxacin against bacteria isolated from Thai patients with urinary tract infections and lower respiratory tract infections.
J Med Assoc Thai
February 2012
Objective: To determine comparative in vitro activity of sitafloxacin against clinical isolates of bacteria from Thai patients with urinary tract infection and those with lower respiratory tract infection.
Material And Method: 1,255 clinical isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterococcus spp, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae and Moraxella catarrhalis isolated from different Thai patients with urinary tract infection and those with lower respiratory tract infection in 2010 were included. The minimum inhibitory concentrations (MICs) of sitafloxacin, ciprofloxacin, levofloxacin, moxifloxacin, imipenem, amikacin, ampicillin, ceftazidime, ceftriaxone, penicillin, piperacillin/tazobactam, vancomycin, azithromycin and trimethoprim/sulfamethoxazole were determined by standard agar dilution method.